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Anti-Interleukin-1β antibody produced in goat

Name: Anti-Interleukin-1β antibody produced in goat
Brand: SIGMA
Price: 565 USD
Availability: InStock

IgG fraction of antiserum

Synonym(s):

Anti-IL-1β

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Size/SKU	Availability	Price
1 mg	Available to ship TODAYfromMILWAUKEE	$565.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00240949

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Neutral, WB

Citations:

$565.00

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Properties

biological source

goat

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse

technique(s)

neutralization: suitable, western blot: suitable

UniProt accession no.

P10749

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Il1b(16176)

Description

General description

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. IL-1β has pleiotrophic activities and is protective against infections by recruitment of neutrophils to the infection site, secretion of cytokines and chemokines and activation of adhesion molecules. IL-1β overproduction has been implicated in many auto-immune and allergic disorders such as Cryopirin-associated periodic syndromes, Muckle-Wells syndrome and skin lesions
Anti-Interleukin-1β antibody specifically reacts with mouse IL-1β. The antibody shows 25% cross reactivity with human recombinant IL-1β.

Immunogen

recombinant mouse IL-1β.

Application

Anti-interleukin-1β may be used to neutralize the biological activity of recombinant mouse IL-1β on mouse T-helper D10.G4.1 cell line at a concentration of 50 picog/ml. No neutralization of the biological activity of recombinant human IL-1β is observed. The antibody may be used for immunoblotting at a working concentration 1-2 μg/ml or a dilution of 1:1000. In immunoblotting applications the antibody shows 25% cross-reactivity with human recombinant IL-1β.

Biochem/physiol Actions

The antibody will neutralize the biological activity of recombinant mouse IL-1β, but not recombinant human IL-1β. The antibody shows ~25% cross-reactivity with recombinant human IL-1β.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	I3392	I7642	I8273
$Anti-Interleukin-1β antibody produced in goat IgG fraction of antiserum$ Sigma-Aldrich I3767 Anti-Interleukin-1β antibody produced in goat	$Anti-Interleukin-1α antibody produced in goat IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich I3392 Anti-Interleukin-1α antibody produced in goat	$Anti-Interleukin-12 antibody produced in goat IgG fraction of antiserum$ Sigma-Aldrich I7642 Anti-Interleukin-12 antibody produced in goat	$Anti-Interleukin-2 antibody produced in goat IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich I8273 Anti-Interleukin-2 antibody produced in goat
description IgG fraction of antiserum	description IgG fraction of antiserum, lyophilized powder	description IgG fraction of antiserum	description IgG fraction of antiserum, lyophilized powder
biological source goat	biological source goat	biological source goat	biological source goat
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum
UniProt accession no. P10749	UniProt accession no. P01582	UniProt accession no. P43431	UniProt accession no. P60568
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Key Documents

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Anti-Interleukin-1β antibody produced in goat

IgG fraction of antiserum

Select a Size

About This Item

I3767-1MG

$565.00

biological source

Quality Segment

conjugate

antibody form

antibody product type

clone

species reactivity

technique(s)

UniProt accession no.

storage temp.

target post-translational modification

Gene Information

General description

Immunogen

Application

Biochem/physiol Actions

Physical form

Preparation Note

Disclaimer

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Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

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