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Monoclonal Anti-Interleukin-1α propeptide antibody produced in mouse

Name: Monoclonal Anti-Interleukin-1α propeptide antibody produced in mouse
Brand: SIGMA
Price: 441 USD
Availability: InStock

clone 409405, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-IL1, Anti-IL1A

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Size/SKU	Availability	Price
100 μg	Available to ship TODAYfromMILWAUKEE	$441.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD00162513

Conjugate:

unconjugated

Clone:

409405, monoclonal

Application:

Citations:

$441.00

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Properties

biological source

mouse

Quality Segment

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

409405, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

western blot: 1-2 μg/mL

isotype

IgG2b

UniProt accession no.

P01583

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL1A(3552)

Description

General description

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced by the activation of NF-κ B transcription factor in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signalling through IL-1 receptor type 1. The IL-1α precursor produced initially is cleaved by calpain to produce a 16 kDa propeptide and 17 kDa mature protein. A variety of cells such as macrophages, epithelial cells, fibroblasts, keratinocytes, monocytes and dendritic cells secrete IL-1α. Both IL-1α and IL-1β are important in acquired immunity, inflammation, response to infection and production of matrix metalloproteinases (MMPs). The propeptide has nuclear localization sequence that enables it to shuttle to nucleus and activate transcription of target genes. The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation.Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis
Monoclonal Anti-Interleukin-1a propeptide recognizes human Interleukin-1α propeptide. It does not cross-react with mature forms of mouse IL-1α or rabbit IL-1α.

Immunogen

purified, E. coli-derived recombinant human interleukin-1α propeptide (aa 1-112).

Application

Anti-interleukin 1α antibody is suitable for immunoblotting at a working concentration of 1-2 μg/ml.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	I8909	I3392	I6784
Sigma-Aldrich I7409 Monoclonal Anti-Interleukin-1α propeptide antibody produced in mouse	$Anti-Interleukin-1α antibody produced in goat IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich I8909 Anti-Interleukin-1α antibody produced in goat	$Anti-Interleukin-1α antibody produced in goat IgG fraction of antiserum, lyophilized powder$ Sigma-Aldrich I3392 Anti-Interleukin-1α antibody produced in goat	Sigma-Aldrich I6784 Monoclonal Anti-Interleukin-2 antibody produced in mouse
description clone 409405, purified immunoglobulin, lyophilized powder	description IgG fraction of antiserum, lyophilized powder	description IgG fraction of antiserum, lyophilized powder	description clone 5334, purified immunoglobulin, lyophilized powder
clone 409405, monoclonal	clone polyclonal	clone polyclonal	clone 5334, monoclonal
biological source mouse	biological source goat	biological source goat	biological source mouse
Gene Information human ... IL1A(3552)	Gene Information human ... IL1A(3552)	Gene Information mouse ... Il1a(16175)	Gene Information human ... IL2(3558)
species reactivity human	species reactivity human	species reactivity mouse	species reactivity human
antibody form purified immunoglobulin	antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form purified immunoglobulin
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated

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Storage Class

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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