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Monoclonal Anti-Interleukin-6 antibody produced in mouse

Name: Monoclonal Anti-Interleukin-6 antibody produced in mouse
Brand: SIGMA
Price: 867 EUR

clone 6708.11, purified immunoglobulin, lyophilized powder

Synonym(s):

Anti-IL-6

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Size/SKU	Availability	Price
0.5 mg	Please contact Customer Service for Availability	€1,020.00 €867.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD00162579

Conjugate:

unconjugated

Clone:

6708.11, monoclonal

Application:

ELISA (i), Neutral, WB

Citations:

€867.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6708.11, monoclonal

form

lyophilized powder

species reactivity

human

technique(s)

indirect ELISA: suitable, neutralization: suitable, western blot: suitable

isotype

IgG1

UniProt accession no.

P05231

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IL6(3569)

Description

General description

Interleukin-6 is a pleotropic cytokine involved in hematopoiesis, inflammation and immune response. IL-6 is secreted by macrophages, dendritic cells and B cells, in response to TNF-α, PGDF and IL-1. The signaling by IL-6 is mediated by heterodimeric receptor, IL-6R, comprising of IL-6Rα (soluble factor) and gp130 (sometimes called IL-6Rβ). gp130 is crucial component for downstream signal transduction. In response to IL-6, gp130 activates kinases of JAK family, STATs, MAPK and Ras proteins. IL-6-mediated signaling is essential for normal development of T and B cells and has been implicated in many diseases such as rheumatoid arthritis, Crohn disease, sepsis, fever, systemic lupus erythematosus, osteoporosis and insulin resistance. Monoclonal Anti-Interleukin-6 antibody recognizes human IL-6. The antibody shows no cross-reactivity with recombinant mouse IL-6 or recombinant human IL-6 sR, OSM, LIF CNTF, or IL-11 or recombinant horse gp130.

Immunogen

recombinant human IL-6.

Application

Monoclonal Anti-Interleukin-6 antibody may be used for ELISA at a minimum antibody concentration of 4 μg/ml. For immunoblotting a working antibody concentration of 1-2 μg/ml may be used. The antibody may be used in neutralization assays; ND50 is 0.01-0.15 μg/ml. For neutralization of IL-6 from human peripheral blood mononuclear cells, a concentration of 2.5 μg/ml was used.

Biochem/physiol Actions

The antibody will neutralize the biological activity of recombinant human IL-6. The antibody shows no cross-reactivity with recombinant mouse IL-6 or recombinant human IL-6 sR, OSM, LIF CNTF, or IL-11 or recombinant horse gp130.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline.

Preparation Note

Purified using protein A.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	WH0003569M1	I2143	I6784
Sigma-Aldrich I7901 Monoclonal Anti-Interleukin-6 antibody produced in mouse	Sigma-Aldrich WH0003569M1 Monoclonal Anti-IL6 antibody produced in mouse	$Anti-Interleukin-6 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich I2143 Anti-Interleukin-6 antibody produced in rabbit	Sigma-Aldrich I6784 Monoclonal Anti-Interleukin-2 antibody produced in mouse
description clone 6708.11, purified immunoglobulin, lyophilized powder	description clone 3E4, purified immunoglobulin, buffered aqueous solution	description IgG fraction of antiserum, buffered aqueous solution	description clone 5334, purified immunoglobulin, lyophilized powder
Gene Information human ... IL6(3569)	Gene Information human ... IL6(3569)	Gene Information human ... IL6(3569)	Gene Information human ... IL2(3558)
biological source mouse	biological source mouse	biological source rabbit	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form IgG fraction of antiserum	antibody form purified immunoglobulin
species reactivity human	species reactivity human	species reactivity human	species reactivity human
clone 6708.11, monoclonal	clone 3E4, monoclonal	clone polyclonal	clone 5334, monoclonal

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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