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I8529

Insulin-like Growth Factor Binding Protein-5 human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

IGFBP-5

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25 μg

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$722.00
$722.00

About This Item

UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD03457235

$722.00

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biological source

human

Quality Segment

recombinant

expressed in NSO cells

assay

>90% (SDS-PAGE)

form

lyophilized powder

potency

0.5-1.5 mg per mL ED50

mol wt

34 kDa by SDS-PAGE (reducing), calculated mol wt ~28 kDa

packaging

pkg of 25 μg

impurities

endotoxin, tested

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... IGFBP5(3488)

General description

The gene IGFBP-5 (insulin-like growth factor binding protein-5) is mapped to human chromosome 2q35.

Biochem/physiol Actions

IGFBP-5 (insulin-like growth factor binding protein-5) interacts with IGFs and thereby controls IGF activity. High levels of IGFBP5 are present in systemic sclerosis and idiopathic pulmonary fibrosis conditions. It also plays a crucial role in cancer progression.
Binds to bone cells and is the predominant insulin-like growth factor binding protein in bone; when binding the extracellular matrix, it modulates IGF activity.
IGFBP-5 binds to bone cells and is the predominant insulin-like growth factor binding protein in bone. When IGFBP-5 binds the extracellular matrix, it modulates IGF activity. Mouse, human, and rat IGFBP-5 share 97% homology.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA.

Analysis Note

The biological activity is measured by its ability to inhibit recombinant human IGF-1 or IGF-II on MCF-7 cells.

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Insulin-like Growth Factor Binding Protein-5 human >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sigma-Aldrich

I8529

Insulin-like Growth Factor Binding Protein-5 human

IGF-Binding Protein-5 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Sigma-Aldrich

SRP3068

IGF-Binding Protein-5 human

Insulin-Like Growth Factor Binding Protein-3 human recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

Sigma-Aldrich

I5278

Insulin-Like Growth Factor Binding Protein-3 human

Insulin-Like Growth Factor Binding Protein-2 human recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

Sigma-Aldrich

I5403

Insulin-Like Growth Factor Binding Protein-2 human

description

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

description

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

description

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

description

recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture, ≥95% (SDS-PAGE)

recombinant

expressed in NSO cells

recombinant

expressed in E. coli

recombinant

expressed in NSO cells

recombinant

expressed in NSO cells

biological source

human

biological source

human

biological source

human

biological source

human

assay

>90% (SDS-PAGE)

assay

≥98% (SDS-PAGE), ≥98% (HPLC)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

form

lyophilized powder

form

lyophilized

form

lyophilized powder

form

lyophilized powder

mol wt

34 kDa by SDS-PAGE (reducing), calculated mol wt ~28 kDa

mol wt

28.6 kDa

mol wt

29 kDa

mol wt

~36 kDa by SDS-PAGE, calculated mol wt ~31 kDa

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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