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Anti-Insulin-Like Growth Factor-I antibody produced in goat

Name: Anti-Insulin-Like Growth Factor-I antibody produced in goat
Brand: SIGMA
Price: 419.9 EUR

affinity isolated antibody

Synonym(s):

Anti-IGF-I

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Size/SKU	Availability	Price
250 μg	Please contact Customer Service for Availability	€494.00 €419.90

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD00162566

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Neutral, WB

Citations:

€419.90

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Properties

biological source

goat

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

neutralization: 3-12 μg/mL, western blot: 0.1-0.2 μg/mL

UniProt accession no.

P05019

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IGF1(3479)

Description

General description

Insulin-like growth factors -1 and -2 are important regulators of signalling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effect of IGF-1 is by endocrine, paracrine and autocrine signalling. The effects of IGF-1 signalling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation. Irregular IGF-1 signaling has been implicated in many cancers including melanoma, breast, lung, colon and prostate
Anti-IGF-I recognizes human insulin-like growth factor I. The antibody does not react with human IGF-II.

Immunogen

recombinant human IGF-I expressed in Escherichia coli

Application

Anti- IGF-1 antibody may be used for neutralization reactions, the ND50 of the antibody is 3-12 μg/ml. For immunoblotting a working antibody concentration of 0.1-0.2 μg/ml.

Biochem/physiol Actions

The antibody neutralizes the biological activity of recombinant human IGF-I.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline, pH 7.4, with 5% trehalose.

Preparation Note

Affinity isolated by IGF-I affinity chromatography.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

1 of 1

This Item	I9409	I2032	H0665
Sigma-Aldrich I8773 Anti-Insulin-Like Growth Factor-I antibody produced in goat	Sigma-Aldrich I9409 Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster	Sigma-Aldrich I2032 Monoclonal Anti-Insulin-Like Growth Factor Binding Protein-1 antibody produced in mouse	Sigma-Aldrich H0665 Monoclonal Anti-Hepatocyte Growth Factor antibody produced in mouse
biological source goat	biological source hamster	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
technique(s) neutralization: 3-12 μg/mL, western blot: 0.1-0.2 μg/mL	technique(s) capture ELISA: 2-8 μg/mL, neutralization: suitable, western blot: 1-2 μg/mL	technique(s) capture ELISA: suitable, neutralization: suitable, western blot: 1-2 μg/mL	technique(s) capture ELISA: 2-8 μg/mL, western blot: 1-2 μg/mL
species reactivity human	species reactivity mouse	species reactivity human	species reactivity human

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Key Documents

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Anti-Insulin-Like Growth Factor-I antibody produced in goat

affinity isolated antibody

Select a Size

About This Item

I8773-250UG

€419.90

biological source

Quality Segment

conjugate

antibody form

antibody product type

clone

form

species reactivity

technique(s)

UniProt accession no.

storage temp.

target post-translational modification

Gene Information

General description

Immunogen

Application

Biochem/physiol Actions

Physical form

Preparation Note

Disclaimer

Compare Similar Items

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Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

ppe

Documentation

Certificates of Analysis (COA)

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