Key Documents

View All Documentation

Anti-Jagged 1 antibody produced in goat

Name: Anti-Jagged 1 antibody produced in goat
Brand: SIGMA
Price: 533.8 USD
Availability: InStock

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-AGS, Anti-AGS1, Anti-AHD, Anti-AWS, Anti-CD339, Anti-CMT2HH, Anti-DCHE, Anti-HJ1, Anti-JAGL1

Select a Size

Change View

Size/SKU	Availability	Price
0.1 mg	Available to ship TODAYfromMILWAUKEE	$628.00 $533.80

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD02096779

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (c), FACS, WB

Citations:

$533.80

List Price$628.00Save 15%

Web-Only Promotion

Available to ship TODAYDetails

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

goat

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

rat

technique(s)

capture ELISA: 0.2-0.8 μg/mL, flow cytometry: 2.5 μg using 10⁶rat cortical stem cells, western blot: 0.1 μg/mL

UniProt accession no.

Q63722

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... JAG1(182)
rat ... Jag1(29146)

Description

General description

Jagged-1 is a Notch ligand. The Notch signaling system regulates proliferation, differentiation, and apoptosis in many tissues, including hematopoietic tissue. Notch is a family of transmembrane receptors activated by ligands (Jagged-1, Jagged-2, and Delta-1) that are expressed on adjacent cells. Hematopoietic stem cells and early progenitors express Notch-1 and Notch-2, whereas primary stromal cultures have been shown to express Jagged-1, indicating that Jagged-1 may play a role in nurturing progenitor cells within the hematopoietic microenvironment. Cells engineered to express high levels of Jagged-1 caused a four-fold increase in formation of hematopoietic progenitor cell colonies. However, without the presence of other cytokines that stimulate proliferation and maturation, such as IL-3, IL-6, SCF and G-CSF, Jagged-1 actually decreased myeloid colony formation of CD34⁺ cells, suggesting that Jagged-1 modulates cytokine signals and helps preserve CD34⁺ cells in an immature state.

Notch signaling is a well conserved among the metazoans and is a regulator of growth, differentiation, and patterning processes. One of the ligands of Notch family receptors is Jagged. Mammalian Jagged family comprises of Jagged-1 and Jagged-2. Jagged proteins are expressed during the critical stages of embryonic and postnatal development. The Notch-Jagged signaling regulates the proliferation of endothelial cells, apoptosis, differentiation of hematopoietic progenitors, skeletal development and formation and differentiation of blood vessels. Notch-jagged pathway components play important role in the pathology of diseases like Alagille syndrome, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) and osteosarcoma. Anti-Jagged 1 antibody specifically recognizes rat Jagged-1.

Immunogen

recombinant rat Jagged 1 extracellular domain, expressed in NSO cells.

Application

Anti-Jagged 1 antibody may be used for ELISA at a working antibody concentration of 0.5-1.0 μg/ml. For immunoblotting, antibody concentration of 0.1-0.2 μg/ml is recommended. For flow cytometry, a concentration of 20 μg/ml (10 μL/10⁵ cells to 10⁶ cells) may be used. The antibody is suitable for neutralization assays (ND50 is ~2-10 μg/ml).

Physical form

lyophilized from a 0.2 μm filtered solution of phosphate buffered saline (PBS), pH 7.4, and 5% trehalose

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	A1104	HPA021555	N8773
Sigma-Aldrich J4127 Anti-Jagged 1 antibody produced in goat	Sigma-Aldrich A1104 Anti-Angiopoietin-1 antibody produced in goat	Sigma-Aldrich HPA021555 Anti-JAG1 antibody produced in rabbit	Sigma-Aldrich N8773 Anti-Nerve Growth Factor-β antibody produced in goat
description affinity isolated antibody, lyophilized powder	description affinity isolated antibody, lyophilized powder	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description affinity isolated antibody, lyophilized powder
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source goat	biological source goat	biological source rabbit	biological source goat
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
species reactivity rat	species reactivity human	species reactivity human	species reactivity rat
shipped in dry ice	shipped in -	shipped in wet ice	shipped in -

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Key Documents

Skip To

Anti-Jagged 1 antibody produced in goat

affinity isolated antibody, lyophilized powder

Select a Size

About This Item

$533.80

biological source

Quality Segment

conjugate

antibody form

antibody product type

clone

form

species reactivity

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Gene Information

General description

Immunogen

Application

Physical form

Disclaimer

Compare Similar Items

This Item

Still not finding the right product?

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Questions

Reviews

Active Filters

Key Documents

Skip To

Anti-Jagged 1 antibody produced in goat

affinity isolated antibody, lyophilized powder

Select a Size

About This Item

J4127-.1MG

$533.80

biological source

Quality Segment

conjugate

antibody form

antibody product type

clone

form

species reactivity

technique(s)

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Gene Information

General description

Immunogen

Application

Physical form

Disclaimer

Compare Similar Items

This Item

Still not finding the right product?

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Questions

Reviews

Active Filters