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JN0002

Loreclezole

≥98% (HPLC)

Synonym(s):

1-[(1Z)-2-Chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-1,2,4-triazole, 1-[(Z)-2-Chloro-2-(2,4-dichlorophenyl)vinyl]-1,2,4-triazole, R 72063, R-72063, R72063

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Size/SKUAvailabilityPrice
25 mg

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$435.00
$451.00

About This Item

Empirical Formula (Hill Notation):
C10H6Cl3N3
CAS Number:
117857-45-1
Molecular Weight:
274.53
UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00865331
Assay:
≥98% (HPLC)
Form:
powder

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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

Cl/C(C1=CC=C(Cl)C=C1Cl)=C\N2N=CN=C2

InChI

1S/C10H6Cl3N3/c11-7-1-2-8(9(12)3-7)10(13)4-16-6-14-5-15-16/h1-6H/b10-4-

InChI key

XGLHZTBDUXXHOM-WMZJFQQLSA-N

Biochem/physiol Actions

Loreclezole (R72063) is a sedative and anticonvulsant that exerts subtype-selective positive allosteric modulator (PAM) potency toward beta2 (β2)- or β3-containing GABAA gamma-aminobutyric acid (GABA) receptors (% potentiation by 1 μM Loreclezole of GABA EC20-stimulated current/human α1βγ2 = 100/α1β2γ2, 120/α1β3γ2, 13/α1β1γ2; α1β2γ2 EC50 = 1 μM) with >300-fold lower β1 affinity, while acting as a negative allosteric modulator (NAM) against the homomeric rho1 (ρ1) GABAA-rho receptor (rat GABAC IC50 = 0.5 μM against GABA EC10-induced current).
Sedative & anticonvulsant with beta2-/beta3- (β2-/β3-) selective GABAA receptor PAM and GABAC (GABAA-rho receptor) NAM activity.

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SML0228AB175A2052
Loreclezole ≥98% (HPLC)

Sigma-Aldrich

JN0002

Loreclezole

Rc-Ome ≥98% (HPLC)

Sigma-Aldrich

SML0228

Rc-Ome

Anti-GABA Antibody serum, Chemicon®

Sigma-Aldrich

AB175

Anti-GABA Antibody

Anti-GABA antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

A2052

Anti-GABA antibody produced in rabbit

description

≥98% (HPLC)

description

≥98% (HPLC)

description

serum, Chemicon®

description

affinity isolated antibody, buffered aqueous solution

form

powder

form

powder

form

-

form

buffered aqueous solution

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ≥10 mg/mL

solubility

-

solubility

-

color

white to beige

color

, light to dark yellow

color

-

color

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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