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K2015

K-252a

From Nonomuraea longicatena, >98%, tyrosine kinase receptor inhibitor, solution

Synonym(s):

SF 2370

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Pack SizeSKUAvailabilityPrice
200 μL
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$296.00

About This Item

Empirical Formula (Hill Notation):
C27H21N3O5
CAS Number:
99533-80-9
Molecular Weight:
467.47
NACRES:
NA.77
PubChem Substance ID:
329817131
UNSPSC Code:
12352200
EC Number:
200-664-3
MDL number:
MFCD00161522
Assay:
>98%
Form:
solution
Quality level:
200

$296.00

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Product Name

K-252a, Ready Made Solution, from Nonomuraea longicatena, >98%

biological source

Nonomuraea longicatena

Quality Level

200

assay

>98%

form

solution

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@]12C[C@](O)(C(=O)OC)[C@](C)(O1)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35

InChI

1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18-,26+,27+/m1/s1

InChI key

KOZFSFOOLUUIGY-SOLYNIJKSA-N

Gene Information

human ... NTRK1(4914)
rat ... Prkca(24680)

Biochem/physiol Actions

K-252a is also a specific inhibitor of Trk (tyrosine kinase) receptors and selectively blocks the effect of nerve growth factor.[1] At lower concentrations, K-252a acts as a neuroprotective compound prompting survival of primary neuronal cultures.[2] K-252a induces cell cycle arrest and apoptosis by inhibiting both Cdc2 and Cdc25c.[3] K-252a improves psoriasis in a SCID mouse-human skin model[4] and also suppresses referred mechanical hypersensitivity and neuropeptide up-regulation associated with acute pancreatitis.

Features and Benefits

This compound is featured on the Met and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Physical form

Supplied as a 0.2 μm-filtered 1 mM solution in dimethyl sulfoxide (DMSO).

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This Item
SML2737HPA070395567051-M
K-252a Ready Made Solution, from Nonomuraea longicatena, >98%

Sigma-Aldrich

K2015

K-252a

AER-271 ≥98% (HPLC)

Sigma-Aldrich

SML2737

AER-271

Anti-KITLG antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody

Sigma-Aldrich

HPA070395

Anti-KITLG antibody produced in rabbit

Sinefungin InSolution, ≥95%, antibiotic

Millipore

567051-M

Sinefungin

assay

>98%

assay

≥98% (HPLC)

assay

-

assay

≥95% (HPLC)

form

solution

form

powder

form

buffered aqueous glycerol solution

form

liquid

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

shipped in

dry ice

shipped in

-

shipped in

wet ice

shipped in

-

biological source

Nonomuraea longicatena

biological source

-

biological source

rabbit

biological source

-

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000469071
0000469071
0000274910
0000243337
0000274910

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Related Content

Data Sheet - K2015

Instructions

M A Glicksman et al.
Journal of neurochemistry, 64(4), 1502-1512 (1995-04-01)
The organic molecule K-252a promoted cell survival, neurite outgrowth, and increased choline acetyltransferase (ChAT) activity in rat embryonic striatal and basal forebrain cultures in a concentration-dependent manner. A two- to threefold increase in survival was observed at 75 nM K-252a
L S Chin et al.
Cancer investigation, 17(6), 391-395 (1999-08-06)
The indole carbazole K252a has been shown in previous studies to inhibit the platelet-derived growth factor signal transduction pathway in gliomas. Because K252a has nonspecific effects on protein kinase function, we studied its effect on cyclin-dependent kinases (CDK) and cell
Winston, J.H., et al.
Pain, 4, 329-337 (2003)
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Global Trade Item Number

SKUGTIN
K2015-200UL04061838031457

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