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K2638

Kallikrein from human plasma

buffered aqueous solution, ≥5 units/mg protein

Synonym(s):

Kininogenase, Kininogenin

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50 μg
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$694.00

About This Item

CAS Number:
9001-01-8
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
3.4.21.34 (BRENDA, IUBMB)
MDL number:
MFCD00131428
Specific activity:
≥5 units/mg protein

$694.00

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form

buffered aqueous solution

Quality Segment

specific activity

≥5 units/mg protein

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... KLK1(3816)

General description

Kallikrein-related peptidases belong to the family of 15 highly conserved trypsin- or chymotrypsin-like serine proteases. Plasma kallikrein (PK) is a serine protease derived from plasma prekallikrein, a zymogen found at higher levels in blood circulation. The KLKB1 gene is located on the human chromosome at 4q35.2.

Application

Kallikrein from human plasma has been used:

  • to culture human hepatocellular carcinoma cell line
  • to study its effects on the cleavage of Neisserial heparin binding antigen (NHBA) from Neisseria meningitidis
  • in peptidase inhibition assay

Biochem/physiol Actions

Plasma kallikrein (PK) is involved in the synthesis of bradykinin, maintaining the blood metabolite levels and hypertension. It also participates in the activation of coagulation factor XII, which promotes inflammation and the intrinsic coagulation pathway. PK controls proteolytic cascades in the cardiovascular system like the kallikrein-kinin system, renin-angiotensin system, fibrinolytic system, and the alternative complement pathway. It is involved in the cleavage of glucagon-like peptide-1 (GLP-1) and neuropeptide Y (NPY) which suggests that plasma kallikrein may affect metabolism and diabetes.

Physical form

Solution in 20 mM Tris-HCl, pH 7.8 with 100 mM NaCl.

Other Notes

One unit will hydrolyze 1.0 μmole of Nα-benzoyl-L-arginine ethyl ester (BAEE) to Nα-benzoyl-L-arginine and ethanol per min at pH 8.7 at 25°C.

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This Item
K3627420307420314
Kallikrein from human plasma buffered aqueous solution, ≥5 units/mg protein

Sigma-Aldrich

K2638

Kallikrein from human plasma

Kallikrein from porcine pancreas ≥40 units/mg protein

Sigma-Aldrich

K3627

Kallikrein from porcine pancreas

Kallikrein, Human Plasma Native Kallikrein from human plasma. A serine protease that releases bradykinin from kininogen. Present in the plasma as an inactive precursor, prokallikrein.

Sigma-Aldrich

420307

Kallikrein, Human Plasma

Kallikrein Substrate, Fluorogenic Sensitive fluorogenic substrate for kallikreins.

Sigma-Aldrich

420314

Kallikrein Substrate, Fluorogenic

description

buffered aqueous solution, ≥5 units/mg protein

description

≥40 units/mg protein

description

Native Kallikrein from human plasma. A serine protease that releases bradykinin from kininogen. Present in the plasma as an inactive precursor, prokallikrein.

description

Sensitive fluorogenic substrate for kallikreins.

specific activity

≥5 units/mg protein

specific activity

≥40 units/mg protein

specific activity

≥15 units/mg protein

specific activity

-

Gene Information

human ... KLK1(3816)

Gene Information

-

Gene Information

-

Gene Information

-

form

buffered aqueous solution

form

solid

form

liquid

form

lyophilized

shipped in

dry ice

shipped in

-

shipped in

-

shipped in

ambient

UniProt accession no.

P06870

UniProt accession no.

-

UniProt accession no.

-

UniProt accession no.

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

Storage Class

12 - Non Combustible Liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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