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Anti-Kindlin-2 antibody produced in rabbit

Name: Anti-Kindlin-2 antibody produced in rabbit
Brand: SIGMA
Price: 612 USD
Availability: InStock

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-FERMT2, Anti-Fermitin family homolog 2, Anti-KIND2, Anti-MIG2, Anti-Mitogen inducible gene 2 protein, Anti-PLEKHC1, Anti-Pleckstrin homology domain containing, family C member 1, Anti-UNC112, Anti-UNC112B

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$612.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, WB

Citations:

$612.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~72 kDa

species reactivity

mouse, rat, canine, human

concentration

~1.0 mg/mL

technique(s)

indirect immunofluorescence: 2-5 μg/mL using canine MDCK cells, western blot: 1-2 μg/mL using whole extracts of human HeLa, mouse P19 or rat AT3B-1 cells

UniProt accession no.

Q96AC1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... FERMT2(10979)
mouse ... Fermt2(218952)
rat ... Fermt2(289992)

Description

General description

Anti-kindlin-2 recognizes human, mouse, rat and canine kindlin-2. Kindlin-2, also known as fermitin family member 2 (FERMT2) or pleckstrin homology domain-containing family C member 1 (PLEKHC1), is encoded by the gene mapped to human chromosome 14q22.1. Kindlin-2 is a member of the kindlin protein family and has a ubiquitous expression pattern.

Application

Anti-kindlin-2 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Kindlin-2 acts as a focal adhesion protein and controls breast cancer progression by promoting genome instability. Kindlin-2, as an integrin-interacting protein, plays a vital role in integrin activation and integrin-mediated cell-extracellular matrix (ECM) interaction. Kindlin-2 expression is associated with poor prognosis of patients with hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinomas (PDACs). Therefore, kindlin-2 can be considered as a potential biomarker for patients with HCC and PDACs.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2-8°C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Other Notes

In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4200465	MAB2617	HPA040505
Sigma-Aldrich K3269 Anti-Kindlin-2 antibody produced in rabbit	Sigma-Aldrich SAB4200465 Anti-Kindlin-1 antibody, Mouse monoclonal	Sigma-Aldrich MAB2617 Anti-Kindlin-2 Antibody, clone 3A3	Sigma-Aldrich HPA040505 Anti-FERMT2 antibody produced in rabbit
description ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution	description clone KN-4, purified from hybridoma cell culture	description clone 3A3, from mouse	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form affinity isolated antibody
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
biological source rabbit	biological source mouse	biological source mouse	biological source rabbit
species reactivity mouse, rat, canine, human	species reactivity mouse, human	species reactivity human	species reactivity human
UniProt accession no. Q96AC1	UniProt accession no. Q9BQL6	UniProt accession no. Q96AC1	UniProt accession no. -

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Storage Class

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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