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K3644

K 858

≥98% (HPLC)

Synonym(s):

K858, N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadia zol-2-yl)acetamide

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Size/SKUAvailabilityPrice
25 mg

Available to ship TODAYfromMILWAUKEE

$292.00

About This Item

Empirical Formula (Hill Notation):
C13H15N3O2S
CAS Number:
Molecular Weight:
277.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$292.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

CC(=O)NC1=NN(C(C)=O)C(C)(S1)c2ccccc2

InChI

1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)

InChI key

JEFVYQYZCAVNTP-UHFFFAOYSA-N

Biochem/physiol Actions

A thiadiazoline derivative reported as a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor.
Eg5 is a key protein involved in the formation of bipolar spindles. K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor. The compound induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells.

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vibrant-m

COLO 858

description

≥98% (HPLC)

description

The Eg5 Inhibitor IV, VS-83, also referenced under CAS 909250-29-9, controls the biological activity of Eg5. This small molecule/inhibitor is primarily used for Cell Structure applications.

description

NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA.

description

For Direct-zol™ RNA kits

assay

≥98% (HPLC)

assay

≥99% (HPLC)

assay

-

assay

-

form

powder

form

solid

form

-

form

-

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−196°C

storage temp.

-

solubility

DMSO: ≥20 mg/mL

solubility

ethanol: 5 mg/mL, DMSO: 50 mg/mL

solubility

-

solubility

-

color

white to off-white

color

white

color

-

color

-


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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