Skip to Content
MilliporeSigma

Skip To

L0649

Leupeptin hydrochloride

powder, ≥70% (HPLC)

Synonym(s):

Acetyl-Leu-Leu-Arg-al hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
5 mg
Check Cart for Availability
$103.00
25 mg
Check Cart for Availability
$361.00
100 mg
Check Cart for Availability
$1,190.00

About This Item

Empirical Formula (Hill Notation):
C20H38N6O4 · HCl
CAS Number:
Molecular Weight:
463.01
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:

$103.00


Check Cart for Availability

​
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Product Name

Leupeptin hydrochloride, microbial, ≥70% (HPLC)

biological source

microbial

Quality Segment

assay

≥70% (HPLC)

form

powder

input

general use sample(s)

solubility

water: 50 mg/mL, clear, colorless to yellow

storage temp.

−20°C

SMILES string

Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O

InChI

1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H

InChI key

OQQYPQNFLLAILR-UHFFFAOYSA-N

Biochem/physiol Actions

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Analysis Note

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
L5793L288411086090001
description

microbial, ≥70% (HPLC)

description

BioUltra, microbial, ≥95% (HPLC)

description

microbial, ≥90% (HPLC)

description

N-Acetyl-Leu-Leu-norleucinal, synthetic

assay

≥70% (HPLC)

assay

≥95% (HPLC)

assay

≥90% (HPLC)

assay

98% (chromatographically homogeneous)

biological source

microbial

biological source

microbial

biological source

microbial

biological source

-

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

-

form

powder

form

powder

form

powder

form

powder

solubility

water: 50 mg/mL, clear, colorless to yellow

solubility

H2O: 50 mg/mL

solubility

H2O: 50 mg/mL, H2O: 10 mM (Solutions are stable for a week at 4 °C. Stock solutions are stable up to 6 months at −20 °C.)

solubility

DMF: 10 mg/mL, methanol: 10 mg/mL

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C


Still not finding the right product?

Explore all of our products under Leupeptin hydrochloride


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library




Questions

Reviews

No rating value

Active Filters