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L109

Lorglumide sodium salt

solid

Synonym(s):

(±)-4-[(3,4-Dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxopentanoic acid sodium salt, CR 1409

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Size/SKUAvailabilityPrice
50 mg
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$185.00

About This Item

Empirical Formula (Hill Notation):
C22H31Cl2N2NaO4
CAS Number:
Molecular Weight:
481.39
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid

$185.00


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form

solid

Quality Segment

color

white

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >10 mg/mL, H2O: 10 mg/mL, methanol: 28 mg/mL

SMILES string

[Na+].CCCCCN(CCCCC)C(=O)C(CCC([O-])=O)NC(=O)c1ccc(Cl)c(Cl)c1

InChI

1S/C22H32Cl2N2O4.Na/c1-3-5-7-13-26(14-8-6-4-2)22(30)19(11-12-20(27)28)25-21(29)16-9-10-17(23)18(24)15-16;/h9-10,15,19H,3-8,11-14H2,1-2H3,(H,25,29)(H,27,28);/q;+1/p-1

InChI key

JCNPYMDDOUQTBK-UHFFFAOYSA-M

Gene Information

human ... CCKAR(886)

Application

Lorglumide sodium salt has been used as a cck-a (cholecystokinin A) receptor antagonist for peptide determination in rat islet cells. It has been used as a CCK1 inhibitor to check the effect of cck1 (cck-a) and cck2 (cck-b) receptors on cerulein-induced upregulation of egr-1 (early growth response 1) expression in rat pancreatic acinar cells.

Biochem/physiol Actions

Potent and selective non-peptide cholecystokinin (CCKA) receptor antagonist; orally active.

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description

solid

description

affinity isolated antibody

description

United States Pharmacopeia (USP) Reference Standard

description

certified reference material, pharmaceutical secondary standard

form

solid

form

buffered aqueous solution

form

-

form

-

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

300

solubility

methanol: 28 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: >10 mg/mL, H2O: 10 mg/mL

solubility

-

solubility

-

solubility

-

Gene Information

human ... CCKAR(886)

Gene Information

human ... CCKAR(886)

Gene Information

human ... CPS1(1373)

Gene Information

-

color

white

color

-

color

-

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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