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Anti-phospho-5-Lipoxygenase (pSer⁵²³) antibody produced in rabbit

Name: Anti-phospho-5-Lipoxygenase (pSer<SUP>523</SUP>) antibody produced in rabbit
Brand: SIGMA
Price: 830 USD
Availability: InStock

affinity isolated antibody, buffered aqueous glycerol solution

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1 vial	Check Cart for Availability	$830.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD08705494

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IHC (p), IP, WB

Citations:

$830.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

human, rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunoprecipitation (IP): suitable, indirect immunofluorescence: suitable, western blot: 1:1,000

UniProt accession no.

P09917

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer523)

Gene Information

human ... ALOX5(240)
rat ... Alox5(25290)

Description

General description

The gene ALOX5 (arachidonate 5-lipoxygenase), also referred to as 5-LOX (5-lipoxygenase), encodes a protein belonging to the lipoxygenase family. The gene is mapped to human chromosome 10q11.21. The protein contains a distinct ‘C2-like′ domain at the amino terminal that is involved in Ca²⁺-dependent membrane binding and a large catalytic domain containing the non-heme catalytic iron. It is highly unstable with short-lived activity.

Immunogen

phosphopeptide corresponding to amino acid residues surrounding the pSer⁵²³ of human 5-lipoxgenase (5-LO).

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biochem/physiol Actions

The gene ALOX5 (arachidonate 5-lipoxygenase) encodes a lipoxygenase that catalyzes the conversion of arachidonic acid (AA) and other fatty acids to bioactive compounds, such as 5(S)-hydroxyeicosatetraenoic acid (5-HETE), leukotriene B4 (LTB4), and other leukotrienes. These leukotrienes and lipoxins function as mediators of inflammatory response. ALOX5 has been implicated in tumorigenesis and may serve as a potential therapeutic target and biomarker.

Physical form

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4501034	HPA071285	SAB5701424
Sigma-Aldrich L1168 Anti-phospho-5-Lipoxygenase (pSer⁵²³) antibody produced in rabbit	Sigma-Aldrich SAB4501034 Anti-Arachidonate 5 Lipoxygenase antibody produced in rabbit	Sigma-Aldrich HPA071285 Anti-ALOX5 antibody produced in rabbit	Sigma-Aldrich SAB5701424 Anti-ALOX5 antibody produced in rabbit
description affinity isolated antibody, buffered aqueous glycerol solution	description affinity isolated antibody	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody	description -
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form -
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in wet ice
clone polyclonal	clone polyclonal	clone polyclonal	clone monoclonal

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Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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