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L1790

L-685,458

>96% (HPLC), solid

Synonym(s):

(5S)-(t-Butoxycarbonylamino)-6-phenyl-(4R)hydroxy-(2R)benzylhexanoyl)-L-leu-L-phe-amide

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Size/SKUAvailabilityPrice
1 mg
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$572.00

About This Item

Empirical Formula (Hill Notation):
C39H52O6N4
CAS Number:
292632-98-5
Molecular Weight:
672.85
NACRES:
NA.77
PubChem Substance ID:
329817393
UNSPSC Code:
12352200
MDL number:
MFCD03093402
Assay:
>96% (HPLC)
Form:
solid

$572.00

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Quality Segment

assay

>96% (HPLC)

form

solid

color

white

solubility

DMSO: >10 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

−20°C

SMILES string

O[C@@H]([C@H](CC1=CC=CC=C1)NC(OC(C)(C)C)=O)C[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CC3=CC=CC=C3)C(N)=O)=O)=O

InChI

1S/C39H52N4O6/c1-26(2)21-33(37(47)41-32(35(40)45)24-29-19-13-8-14-20-29)42-36(46)30(22-27-15-9-6-10-16-27)25-34(44)31(23-28-17-11-7-12-18-28)43-38(48)49-39(3,4)5/h6-20,26,30-34,44H,21-25H2,1-5H3,(H2,40,45)(H,41,47)(H,42,46)(H,43,48)/t30-,31+,32+,33+,34-/m1/s1

InChI key

MURCDOXDAHPNRQ-ZJKZPDEISA-N

Gene Information

Application

L-685,458 has been used to attenuate Notch signalling in ovary culture. It has also been used to analyze the specificity of the γ-secretase activity in brain tissue samples.

Biochem/physiol Actions

L-685,458 is a potent, selective, structurally novel γ-secretase inhibitor; equipotent inhibitor of both Aβ1-42 and Aβ1-40 production.
L-685,458 mimics the transition state in aspartyl protease. It possesses an IC50 of 17nM with respect to inhibition of Aβ synthesis. It is known to block Notch (neurogenic locus notch homolog protein) signaling, which in turn reduces ERK (extracellular signal regulated kinase) phosphorylation by EGF (epidermal growth factor). L-685,458 targets the active site and substrate binding site of the enzyme.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Manufactured and sold under license from Merck & Co., Inc., Kenilworth, NJ, U.S.

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This Item
D5942EMU021131EHU148421
L-685,458 >96% (HPLC), solid

Sigma-Aldrich

L1790

L-685,458

DAPT ≥98% (HPLC), solid

Sigma-Aldrich

D5942

DAPT

MISSION® esiRNA targeting mouse Notch4

Sigma-Aldrich

EMU021131

MISSION® esiRNA

MISSION® esiRNA targeting human NOTCH4

Sigma-Aldrich

EHU148421

MISSION® esiRNA

description

>96% (HPLC), solid

description

≥98% (HPLC), solid

description

targeting mouse Notch4

description

targeting human NOTCH4

form

solid

form

solid

form

lyophilized powder

form

lyophilized powder

assay

>96% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: >10 mg/mL

solubility

DMSO: ~18 mg/mL

solubility

-

solubility

-

color

white

color

white

color

-

color

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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