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L2037

β-Lapachone

synthetic (organic), ≥98% (TLC), DNA topoisomerase typeI inhibitor, powder

Synonym(s):

ARQ 501, NSC 26326, NSC 629749, SL 11001

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Size/SKUAvailabilityPrice
5 mg
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$215.00

About This Item

Empirical Formula (Hill Notation):
C15H14O3
CAS Number:
Molecular Weight:
242.27
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (TLC)
Form:
powder

$215.00


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Product Name

β-Lapachone, ≥98% (TLC)

biological source

synthetic (organic)

Quality Segment

assay

≥98% (TLC)

form

powder

SMILES string

CC1(C)CCC2=C(O1)c3ccccc3C(=O)C2=O

InChI

1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3

InChI key

QZPQTZZNNJUOLS-UHFFFAOYSA-N

Application

β-Lapachone has been used:
  • as an anticancer compound in catalase-inhibitable luminol/hydrogen peroxide (HRP)-dependent chemiluminometric assay in Lewis lung carcinoma (LLC) cells and isolated mitochondria
  • as a naphthoquinone to study its effects on the growth and differentiation of mice granulocyte and macrophage progenitor cells
  • as a substrate to study the enzyme activity of human recombinant NAD(P)H dehydrogenase 1 (NQO1) protein

Biochem/physiol Actions

β-Lapachone acts as a DNA topoisomerase type I inhibitor. It exhibits anti-fungal, anti-bacterial, trypanocidal, and antiviral properties. β-Lapachone also inhibits nitric oxide (NO) and inducible NO synthase (iNOS) in alveolar macrophages.
β-Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties. Induces apoptosis in HL-60 and human prostate cancer cells.

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This Item
C9623SML1852N9162
description

≥98% (TLC)

description

from Chaetomium cochliodes, ≥98% (HPLC)

description

≥98% (HPLC)

description

≥90% (SDS-PAGE), ~0.5 mg/mL

form

powder

form

powder

form

powder

form

solution

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥90% (SDS-PAGE)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

200

biological source

synthetic (organic)

biological source

Chaetomium cochliodes

biological source

-

biological source

-


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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