L3408
Transforming Growth Factor-β1 Latency Associated Peptide human
≥97% (SDS-PAGE), recombinant, expressed in Sf21 cells, lyophilized powder, suitable for cell culture
Synonym(s):
LAP, TGF-β1
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
25 μg | Check Cart for Availability | $879.00 |
About This Item
biological source
human
Quality Segment
recombinant
expressed in Sf21 cells
assay
≥97% (SDS-PAGE)
form
lyophilized powder
mol wt
protein 70 kDa
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
suitability
suitable for molecular biology
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... TGFB1(7040)
General description
TGF-β is released from degranulating platelets and secreted from nearly all cells in a biologically inactive complex which is unable to bind to cellular receptors and is not recognized by antibodies to TGF-β. The peptide can be activated by acidification, alkalinization, or action of chaotropic agents in vitro. The complex consists of TGF-β associated non-covalently with a protein designated as the latency associated peptide (LAP). TGF-β and LAP represent components of a pro-peptide that is cleaved in a post-golgi compartment prior to secretion. The recombinant human LAP is produced from a DNA sequence corresponding to the 278 amino acid residues of pre-pro-TGF-β1 terminating prior to the mature TGF-β1. LAP contains a Cys33 to Ser33 substitution. LAP contains 249 amino acids, generated after cleavage of a 29 amino acid residue signal peptide. LAP is a glycoslyated, disulfide linked homodimer.
Application
Biochem/physiol Actions
Physical form
Analysis Note
Disclaimer
1 of 1
This Item | |||
|---|---|---|---|
| description ≥97% (SDS-PAGE), recombinant, expressed in Sf21 cells, lyophilized powder, suitable for cell culture | description TGF-β1, Xeno-free, recombinant, expressed in HEK 293 cells, suitable for cell culture | description recombinant (CHO cells) | description TGF-β1, recombinant, expressed in CHO cells, powder, suitable for cell culture |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) cell culture | mammalian: suitable |
| biological source human | biological source human | biological source human | biological source human |
| recombinant expressed in Sf21 cells | recombinant expressed in HEK 293 cells | recombinant expressed in CHO cells | recombinant expressed in CHO cells |
| assay ≥97% (SDS-PAGE) | assay ≥95% (SDS-PAGE) | assay >95% (SDS-PAGE) | assay ≥95% (SDS-PAGE) |
| form lyophilized powder | form lyophilized powder | form solution | form powder |
| mol wt protein 70 kDa | mol wt dimer 25 kDa (non-glycosylated) | mol wt 25,000 Da | mol wt dimer (12.8/25.6 kDa (112/224 aa)) |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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