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L3770

Lactoferrin from human milk

Iron saturated, ≥85% (SDS-PAGE)

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5 mg

Estimated to ship onAugust 17, 2026fromMILWAUKEE

$284.00
25 mg
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$1,010.00
$858.50
100 mg

Estimated to ship onAugust 17, 2026fromMILWAUKEE

$3,230.00

About This Item

CAS Number:
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
Form:
powder
Assay:
≥85% (SDS-PAGE)
Biological source:
human milk
Mol wt:
82.4 kDa

$284.00


Estimated to ship onAugust 17, 2026Details


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biological source

human milk

Quality Segment

assay

≥85% (SDS-PAGE)

form

powder

mol wt

82.4 kDa

Iron content

0.15-1.0%

technique(s)

microbiological culture: suitable

solubility

phosphate buffer: 10 mg/mL at 25 °C (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4)

UniProt accession no.

storage temp.

2-8°C

SMILES string

N([C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)O)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)N)C)CC(=O)O

InChI

1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44-28(17(3)4)35(55)56/h7-11,16-19,21-23,27-28H,12-15,36H2,1-6H3,(H2,37,45)(H,38,49)(H,39,51)(H,40,54)(H,41,46)(H,42,50)(H,43,53)(H,44,52)(H,47,48)(H,55,56)/t18-,19-,21-,22-,23-,27-,28-/m0/s1

InChI key

QCBUWCQOKPLTDZ-PKRULZLPSA-N

Gene Information

human ... LTF(4057)

Application

Lactoferrin was used to grow Streptococcus mutans in an iron-limiting medium. It was used to test if lactoferrin impedes epithelial cell adhesion in vitro. It was also used to test the diagnostic value of blood cytokine concentrations in acute pneumonia.

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

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This Item
L0520L9507L4765
description

Iron saturated, ≥85% (SDS-PAGE)

description

≥85% (SDS-PAGE), lyophilized powder

description

≥85% (SDS-PAGE)

description

≥85% (SDS-PAGE)

biological source

human milk

biological source

human milk

biological source

bovine milk

biological source

bovine colostrum

technique(s)

microbiological culture: suitable

technique(s)

microbiological culture: suitable

technique(s)

fractionation: suitable

technique(s)

electrophoresis: suitable, ion chromatography: suitable

assay

≥85% (SDS-PAGE)

assay

≥85% (SDS-PAGE)

assay

≥85% (SDS-PAGE)

assay

≥85% (SDS-PAGE)

form

powder

form

lyophilized powder

form

powder

form

powder

mol wt

82.4 kDa

mol wt

82.4 kDa

mol wt

~87 kDa

mol wt

~90 kDa

Gene Information

human ... LTF(4057)

Gene Information

human ... LTF(4057)

Gene Information

cow ... LTF(280846)

Gene Information

cow ... LTF(280846)


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