This product is not considered to be apo form of Lactoferrin. While iron is expected to be present, there are no confirmatory tests performed to document the amount of iron on a batch-to-batch basis.
L4894
Lactoferrin from human milk
powder, BioReagent, suitable for cell culture
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Estimated to ship onOctober 27, 2026fromMILWAUKEE | $133.00 |
25 mg | Available to ship TODAYfromMILWAUKEE | $491.00 |
100 mg | Estimated to ship onOctober 27, 2026fromMILWAUKEE | $1,550.00 |
About This Item
product line
BioReagent
Quality Segment
assay
≥85% (SDS-PAGE)
form
powder
mol wt
82.4 kDa
technique(s)
cell culture | mammalian: suitable
color
white to light red
solubility
PBS, pH 7.4: 1 mg/mL, clear to slightly hazy (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4, at 25 °C)
UniProt accession no.
shipped in
ambient
storage temp.
2-8°C
SMILES string
N([C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)O)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)N)C)CC(=O)O
InChI
1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44-28(17(3)4)35(55)56/h7-11,16-19,21-23,27-28H,12-15,36H2,1-6H3,(H2,37,45)(H,38,49)(H,39,51)(H,40,54)(H,41,46)(H,42,50)(H,43,53)(H,44,52)(H,47,48)(H,55,56)/t18-,19-,21-,22-,23-,27-,28-/m0/s1
InChI key
QCBUWCQOKPLTDZ-PKRULZLPSA-N
Gene Information
human ... LTF(4057)
General description
Application
Lactoferrin from human milk has been used:
- to test its neuroprotective effect on neuroblastoma cells and mouse mesencephalic dopaminergic cell lines MN9D
- to test its antioxidative effect in Edible Bird′s Nest (EBN) induced toxicity in human neuroblastoma SH-SY5Y cells using oxygen radical absorbance capacity (ORAC) assay and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay
- in the preparation of immobilized titanium substrate for testingMG-63 osteoblast activity
- as a low-density lipoprotein (LDL) receptor-related protein (LRP1) ligand in vascular smooth muscle cells (VSMC)
Biochem/physiol Actions
Lactoferrin is blood-brain barrier (BBB) traversable and has therapeutic potential to regulate inflammation, immunity and apoptosis in Parkinson′s disease. It promotes the expression of brain-derived neurotrophic factor (BDNF) via various signaling pathways and aids protection in motor dysfunction. Lactoferrin favors osteogenic differentiation and proliferation of human adipose-derived stem cells (hADSCs). It exhibits proteolytic activity on Haemophilus influenzae colonization factors. Lactoferrin is also a nutraceutical and a potential marker in the pathophysiology of inflammatory bowel diseases, leukocytes
Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.
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This Item | |||
|---|---|---|---|
| description powder, BioReagent, suitable for cell culture | description Iron saturated, ≥85% (SDS-PAGE) | description iron-saturated, ≥85% (GE) | description ≥85% (SDS-PAGE), lyophilized powder |
| technique(s) cell culture | mammalian: suitable | technique(s) microbiological culture: suitable | technique(s) - | technique(s) microbiological culture: suitable |
| form powder | form powder | form solid | form lyophilized powder |
| shipped in ambient | shipped in - | shipped in - | shipped in - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility PBS, pH 7.4: 1 mg/mL, clear to slightly hazy (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4, at 25 °C) | solubility phosphate buffer: 10 mg/mL at 25 °C (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4) | solubility 0.05 M NaCl: 1 mg/mL, clear to faintly turbid, faintly red to brown | solubility phosphate buffer: 1 mg/mL, clear to slightly hazy (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4, at 25 °C) |
| Quality Level 200 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
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Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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Dear customer service, is the lactoferrin in its apo form?
1 answer-
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Could you confirm whether products SRP6519 and L4894 Lactoferrin derived from human milk have confirmed iron content?
1 answer-
The specification sheets for products SRP and L4894 do not mention testing for iron. The product SRP6519 undergoes basic testing, including appearance and SDS Page electrophoresis. On the other hand, product L4894 undergoes more detailed testing, including appearance, solubility, protein by biuret, SDS Page electrophoresis, as well as additional testing for infectious agents and use in cell culture. While iron is expected to be present, there are no confirmatory tests performed to document the amount of iron on a batch-to-batch basis.
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