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L6295

Lomerizine dihydrochloride

≥98% (HPLC), powder

Synonym(s):

1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride

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Size/SKUAvailabilityPrice
50 mg

Available to ship TODAYfromMILWAUKEE

$390.00
$404.00

About This Item

Empirical Formula (Hill Notation):
C27H30F2N2O3·2HCl
CAS Number:
101477-54-7
Molecular Weight:
541.46
NACRES:
NA.25
PubChem Substance ID:
329817637
UNSPSC Code:
12352200
MDL number:
MFCD01703867
Assay:
≥98% (HPLC)
Form:
powder

$404.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥30 mg/mL

storage temp.

2-8°C

SMILES string

Cl.Cl.COc1ccc(CN2CCN(CC2)C(c3ccc(F)cc3)c4ccc(F)cc4)c(OC)c1OC

InChI

1S/C27H30F2N2O3.2ClH/c1-32-24-13-8-21(26(33-2)27(24)34-3)18-30-14-16-31(17-15-30)25(19-4-9-22(28)10-5-19)20-6-11-23(29)12-7-20;;/h4-13,25H,14-18H2,1-3H3;2*1H

InChI key

LOGVKVSFYBBUAJ-UHFFFAOYSA-N

Biochem/physiol Actions

Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator.
Lomerizine dihydrochloride is a voltage-dependent calcium channel blocker and selective cerebral vasodilator. It is one of the most selective calcium channel blockers for the CNS and cerebral arteries. It has been reported to inhibit both T-type and L-type Ca2+ currents in rat hippocampal CA1 pyramidal neurons, to prevent glutamate-induced neurotoxicity in rat hippocampal primary cell cultures, and to exhibit protective effects in animal models of migraine, ischemia and hypoxia. In Japan, lomerizine has been used as the first-line prophylactic drug for migraines.

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This Item
C0980650BML000831193356
Lomerizine dihydrochloride ≥98% (HPLC), powder

Sigma-Aldrich

L6295

Lomerizine dihydrochloride

Cetirizine dihydrochloride European Pharmacopoeia (EP) Reference Standard

C0980650

Cetirizine dihydrochloride

4-(4-Isopropylpiperizinyl)phenylboronic acid, pinacol ester AldrichCPR

Sigma-Aldrich

BML00083

4-(4-Isopropylpiperizinyl)phenylboronic acid, pinacol ester

Iscotrizinol United States Pharmacopeia (USP) Reference Standard

USP

1193356

Iscotrizinol

description

≥98% (HPLC), powder

description

European Pharmacopoeia (EP) Reference Standard

description

AldrichCPR

description

United States Pharmacopeia (USP) Reference Standard

form

powder

form

-

form

solid

form

-

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

2-8°C

solubility

DMSO: ≥30 mg/mL

solubility

-

solubility

-

solubility

-

color

white to tan

color

-

color

-

color

-

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Codes

H302,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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