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L6385

α-Lactalbumin from bovine milk

For use as a marker in SDS-PAGE

Synonym(s):

alpha-lactalbumin

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1 vial

Available to ship TODAYfromMILWAUKEE

$73.10

About This Item

CAS Number:
9051-29-0
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00162025
Biological source:
bovine milk
Form:
powder
Technique(s):
electrophoresis: suitable
Concentration:
>5 mg per vial protein (biuret)

$73.10

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biological source

bovine milk

Quality Segment

200

form

powder

mol wt

~14.2 kDa

packaging

vial of 5 mg

concentration

>5 mg per vial protein (biuret)

technique(s)

electrophoresis: suitable

solubility

H2O: soluble 10 mg/mL

UniProt accession no.

P00711

storage temp.

2-8°C

Gene Information

cow ... LALBA(281894)

General description

α-Lactalbumin is a small, globular, whey protein that has been found in all milk studied to date. It is a metalloprotein of approximately 14 kDa produced in the mammary glands.

Application

α-Lactalbumin from bovine milk is suitable for use:
  • as an electrophoresis marker, with a molar mass of approximately 14,200Da
  • in a study to investigate selective binding of proteins on charged surface iron oxide nanoparticles via reverse charge parity model
α-Lactalbumin was used in the reduction of the antigenicity of whey proteins by lactic acid fermentation.

Biochem/physiol Actions

α-Lactalbumin consists of a single polypeptide chain with 8 cysteines which form disulfide bridges. α-Lactalbumin binds several metal ions, including calcium, which is thought to play a role in the regeneration of native α-lactalbumin from the reduced, denatured form. α-Lactalbumin also has a distinct zinc binding site that is thought to play a role in the binding of the lactose synthase complex. The mature protein consists of 123 amino acid residues (14 kD), and it has a three-dimensional structure with 1.7 Angstrom resolution, demonstrating four a-helices and a triple stranded antiparallel β-sheet.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase. Site-directed mutagenesis of Asp87 or Asp88 to Ala completely abolishes the strong calcium binding affinity and reduces the stimulation of lactose synthase to <3.5% of the maximal rate.

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Sigma-Aldrich

L0130

β-Lactoglobulin from bovine milk

description

For use as a marker in SDS-PAGE

description

Type I, ≥85% (PAGE), lyophilized powder

description

Marker for non-denaturing PAGE

description

≥90% (PAGE), lyophilized powder

technique(s)

electrophoresis: suitable

technique(s)

cell culture | mammalian: suitable, electrophoresis: suitable

technique(s)

microbiological culture: suitable

technique(s)

-

biological source

bovine milk

biological source

bovine milk

biological source

bovine milk

biological source

bovine milk

Quality Level

200

Quality Level

300

Quality Level

200

Quality Level

300

form

powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

Gene Information

cow ... LALBA(281894)

Gene Information

cow ... LALBA(281894)

Gene Information

cow ... LALBA(281894)

Gene Information

bovine ... LGB(280838)

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

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