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Anti-Muscarinic Acetylcholine Receptor (M₃) antibody produced in rabbit

Name: Anti-Muscarinic Acetylcholine Receptor (M<SUB>3</SUB>) antibody produced in rabbit
Brand: SIGMA
Price: 1030 USD
Availability: InStock

affinity isolated antibody, lyophilized powder

Synonym(s):

Muscarinic Acetylcholine Receptor M3 Antibody, Muscarinic Acetylcholine Receptor M3 Antibody - Anti-Muscarinic Acetylcholine Receptor (M3) antibody produced in rabbit

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$1,030.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD06798471

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

$1,030.00

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Properties

Quality Segment

200

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, rat, human

technique(s)

western blot: 1:200 using rat brain lysate

UniProt accession no.

P20309

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CHRM3(1131)
mouse ... Chrm3(12671)
rat ... Chrm3(24260)

Description

General description

Cholinergic receptor muscarinic 3 (CHRM3) gene is located on the human chromosome at 1q43 and encodes for the M3 subtype of muscarinic acetylcholine (ACh) receptors. Muscarinic receptor 3 (M3R) is one of the five muscarinic receptors (M1R-M5R). It is a member of the class A family of G-protein coupled receptors (GPCRs). M3R is localized to the salivary glands, lachrymal glands, trachea and bronchi.

Immunogen

synthetic peptide corresponding to amino acid residues 461-479 of the third intracellular loop of rat muscarinic acetylcholine receptor M₃. This sequence is identical in human, mouse, pig, and bovine.

Application

Anti-Muscarinic Acetylcholine Receptor (M3) antibody produced in rabbit has been used in immunohistochemistry and western blotting.

Rabbit polyclonal anti-Muscarinic Acetylcholine Receptor (M3) antibody is used to tag muscarinic acetylcholine receptor (M3) for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of muscarinic acetylcholine receptor (M3) in information processing and plastic changes in CNS function.

Biochem/physiol Actions

Muscarinic receptor 3 (M3R) is involved in the contraction of the detrusor muscle. It is also involved in the secretion of saliva and bladder contraction. It participates in several pathological processes of lung disease, such as chronic obstructive pulmonary disease (COPD). Mutations in the CHRM3 gene is associated with congenital bladder malformations related to prune-belly-like syndrome (PBS).

Rabbit polyclonal anti-Muscarinic Acetylcholine Receptor (M3) antibody recognizes rat, human, mouse Muscarinic Acetylcholine Receptor (M3).

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	WH0001129M1	HPA013172	SAB4500244
Sigma-Aldrich M0194 Anti-Muscarinic Acetylcholine Receptor (M₃) antibody produced in rabbit	Sigma-Aldrich WH0001129M1 Monoclonal Anti-CHRM2 antibody produced in mouse	Sigma-Aldrich HPA013172 Anti-CHRM5 antibody produced in rabbit	Sigma-Aldrich SAB4500244 Anti-CHRM1 antibody produced in rabbit
description affinity isolated antibody, lyophilized powder	description clone 4B5, purified immunoglobulin, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description affinity isolated antibody
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
UniProt accession no. P20309	UniProt accession no. P08172	UniProt accession no. P08912	UniProt accession no. P11229
Gene Information human ... CHRM3(1131) mouse ... Chrm3(12671) rat ... Chrm3(24260)	Gene Information human ... CHRM2(1129)	Gene Information human ... CHRM5(1133)	Gene Information human ... CHRM1(1128)

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pictograms

GHS06

signalword

Danger

hcodes

H302 + H332,H311,H412

pcodes

P273 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c