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M0321

MDM2, GST-tagged human

recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥75% (SDS-PAGE)

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10 μg
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$233.00

About This Item

NACRES:
NA.77
UNSPSC Code:
12352202
Form:
buffered aqueous glycerol solution
Assay:
≥75% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
~84 kDa

$233.00

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biological source

human

Quality Segment

recombinant

expressed in E. coli

description

contains an N-terminal GST tag

assay

≥75% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~84 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MDM2(4193)

General description

Murine double minute 2 (MDM2) encoding gene is localized at 12q15 in the human chromosome. It is a multidomain nuclear phosphoprotein. It possesses really interesting new gene (RING) finger domain and its function and structural integrity is required for the action of MDM2. It also has central acidic domain.

Biochem/physiol Actions

Overexpression of Murine double minute 2 (MDM2) is observed in various cancer like lung, gastric, colorectal, hepatocellular, breast, endometrial, and prostate. A common single nucleotide polymorphism is observed at 309 amino acid (from T to G) increases the susceptibility to cancer.
Murine double minute 2 (MDM2) is a chief regulator of the p53 tumor suppressor protein. It is a multifunctional oncoprotein that contributes to both p53-dependent and -independent roles in oncogenesis. MDM2 has various p53-independent functions that contribute to its activity as an oncogene.
MDM2 is a negative regulator of the p53 tumor suppressor.
Mdm2 functions as an E3 ubiquitin ligase and an inhibitor of p53 transcriptional activation.

Physical form

Solution in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF and 25% glycerol.

Preparation Note

Supplied as a truncated version (202-end) with an N-terminal GST tag

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MDM2, GST-tagged human recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥75% (SDS-PAGE)

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Sigma-Aldrich

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Anti-MDM2 Antibody, clone IF2 clone IF2, from mouse

Sigma-Aldrich

MABE340

Anti-MDM2 Antibody, clone IF2

description

recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥75% (SDS-PAGE)

description

recombinant, expressed in E. coli, ≥80% (SDS-PAGE), buffered aqueous solution

description

affinity isolated antibody

description

clone IF2, from mouse

assay

≥75% (SDS-PAGE)

assay

≥80% (SDS-PAGE)

assay

-

assay

-

biological source

human

biological source

human

biological source

rabbit

biological source

mouse

recombinant

expressed in E. coli

recombinant

expressed in E. coli

recombinant

-

recombinant

-

mol wt

~84 kDa

mol wt

~57.8 kDa

mol wt

antigen 55 kDa

mol wt

-

form

buffered aqueous glycerol solution

form

buffered aqueous solution, frozen liquid

form

buffered aqueous solution

form

-

UniProt accession no.

Q00987

UniProt accession no.

Q00987

UniProt accession no.

Q00987

UniProt accession no.

Q00987

Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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