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Anti-p38 MAP Kinase antibody produced in rabbit

Name: Anti-p38 MAP Kinase antibody produced in rabbit
Brand: SIGMA
Price: 557 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$557.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.44

MDL number:

MFCD00803556

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, WB

Citations:

$557.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 40 kDa

species reactivity

mouse, rat

technique(s)

microarray: suitable, western blot: 1:10,000 using NIH3T3 mouse fibroblast lysate and rat brain extract

UniProt accession no.

P63086

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAPK1(5594)
mouse ... Mapk1(26413)
rat ... Mapk1(116590)

Description

General description

P38 MAPK is a mitogen-activated protein kinase (MAPK) that belongs to serine/threonine protein kinases family and is activated in response to stress signals like- osmolarity changes, UV-irradiation, heat shock,cytokines and lipopolysaccharides (LPS). It mainly expresses in brain, muscle, thymus, spleen, heart, lung, kidney and fibroblasts.

Immunogen

synthetic peptide K-DEVISFVPPPLDQEEMES derived from the C-terminus of mouse p38 MAP kinase (amino acids 343-360 with N-terminally added lysine) as immunogen. This sequence is highly conserved in human and rat p38 MAP kinase.

Application

Anti-p38 MAP Kinase antibody has been used in western blotting (diluted 1:1000) using using NIH 3T3 mouse fibroblasts cell lysate and rat brain extract. It has also been used in microarray.

Biochem/physiol Actions

Mitogen-activated protein kinases (MAP kinases, MAPKs) are a family of protein kinases which are considered to play a crucial role in signal transduction pathways in mammalian cells by leading mitogenic signals to their intracellular targets. MAP kinases regulate several cellular processes, such as proliferation, differentiation, response to stress and oncogenesis. p38 MAPK is activated in response to stress signals like- osmolarity changes, ultravoilet-irradiation, heat shock, cytokines and lipopolysaccharides (LPS). It is required for phosphorylation of MAPK-activated protein kinase 2 (MAPKAPK-2). Anti-p38 MAP Kinase antibody can be used to study the differential tissue expression, specific activation requirements and intracellular localization of MAP kinase isoforms in normal and neoplastic tissues.

Rabbit anti-p38 MAP Kinase antibody reacts specifically with p38 MAP kinase from mouse and rat.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	M8177	SAB5600059	506148
$Anti-p38 MAP Kinase antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich M0800 Anti-p38 MAP Kinase antibody produced in rabbit	Sigma-Aldrich M8177 Anti-p38 MAP Kinase, Activated (Diphosphorylated p38) antibody, Mouse monoclonal	Sigma-Aldrich SAB5600059 Anti-p38 MAPK antibody, Rabbit monoclonal	Sigma-Aldrich 506148 p38 MAP Kinase Inhibitor III
description IgG fraction of antiserum, buffered aqueous solution	description clone P38-TY, purified from hybridoma cell culture, buffered aqueous solution	description recombinant, expressed in HEK 293 cells, clone RM245, purified immunoglobulin	description InSolution, ≥98%
Quality Level 200	Quality Level 200	Quality Level -	Quality Level 100
biological source rabbit	biological source mouse	biological source -	biological source -
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate -
antibody form IgG fraction of antiserum	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C
shipped in dry ice	shipped in dry ice	shipped in wet ice	shipped in wet ice

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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