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M1387

4-Methylpyrazole hydrochloride

alcohol dehydrogenase inhibitor

Synonym(s):

Fomepizole

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Size/SKUAvailabilityPrice
100 mg

Available to ship TODAYfromMILWAUKEE

$167.00
500 mg

Available to ship TODAYfromMILWAUKEE

$556.00
$472.60
1 g

Estimated to ship onSeptember 30, 2026fromMILWAUKEE

$948.00

About This Item

Empirical Formula (Hill Notation):
C4H6N2 · HCl
CAS Number:
Molecular Weight:
118.56
NACRES:
NA.77
PubChem Substance ID:
MDL number:
UNSPSC Code:
12352100

$167.00


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biological source

synthetic (organic)

Quality Segment

assay

≥95%

form

powder

mp

157-159  °C

solubility

methanol: 100 mg/mL, clear, colorless to yellow

storage temp.

2-8°C

SMILES string

Cl.Cc1cn[nH]c1

InChI

1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H

InChI key

PUCXJHNDMYZOHG-UHFFFAOYSA-N

Gene Information

Application

4-Methylpyrazole hydrochloride has been used:
  • as a cytochrome P450 2E1 inhibitor
  • as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells
  • to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells

Useful as an antidote in methanol and ethylene glycol poisoning.

Biochem/physiol Actions

4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.
Alcohol dehydrogenase inhibitor

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This Item
M6500SAB5700849SAB1401005
description

alcohol dehydrogenase inhibitor

description

≥98% (titration)

description

-

description

purified immunoglobulin, buffered aqueous solution

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

rabbit

biological source

rabbit

assay

≥95%

assay

≥98% (titration)

assay

-

assay

-

Gene Information

human ... ADH1A(124), ADH1B(125), ADH1C(126)

Gene Information

-

Gene Information

human ... ADH1C(126)

Gene Information

human ... ADH1C(126)

Quality Level

200

Quality Level

300

Quality Level

100

Quality Level

100

form

powder

form

powder or crystals

form

buffered aqueous solution

form

buffered aqueous solution

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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