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M3949

MST-312

≥98% (HPLC)

Synonym(s):

N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$129.00
$109.65
25 mg

Available to ship TODAYfromMILWAUKEE

$418.00

About This Item

Empirical Formula (Hill Notation):
C20H16N2O6
CAS Number:
Molecular Weight:
380.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$109.65

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

off-white to light tan

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O

InChI

1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)

InChI key

MIQUEZGHEJGPJB-UHFFFAOYSA-N

Application

MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast.

Biochem/physiol Actions

MST-312 is a telomerase Inhibitor.
MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.

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This Item
581011SML1604SML0235
description

≥98% (HPLC)

description

The Telomerase Inhibitor IX, also referenced under CAS 368449-04-1, controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

solid

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 5 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: ≥5 mg/mL at warmed to 60 °C

color

off-white to light tan

color

white

color

white to beige

color

white to beige


Storage Class

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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