MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast.
Biochem/physiol Actions
MST-312 is a telomerase Inhibitor.
MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.
The Telomerase Inhibitor IX, also referenced under CAS 368449-04-1, controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.
description
≥98% (HPLC)
description
≥98% (HPLC)
form
powder
form
solid
form
powder
form
powder
assay
≥98% (HPLC)
assay
≥95% (HPLC)
assay
≥98% (HPLC)
assay
≥98% (HPLC)
Quality Level
100
Quality Level
100
Quality Level
100
Quality Level
100
storage temp.
2-8°C
storage temp.
−20°C
storage temp.
2-8°C
storage temp.
2-8°C
solubility
DMSO: ≥20 mg/mL
solubility
DMSO: 5 mg/mL
solubility
DMSO: 10 mg/mL, clear
solubility
DMSO: ≥5 mg/mL at warmed to 60 °C
color
off-white to light tan
color
white
color
white to beige
color
white to beige
Storage Class
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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