Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

M4565

Matrix Metalloproteinase-7 human

~0.1 mg/mL, recombinant, expressed in E. coli, buffered aqueous solution

Synonym(s):

MMP-7, Matrilysin-1

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
10 μg
Check Cart for Availability
$582.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
EC Number:
3.4.24.23 (BRENDA, IUBMB)
MDL number:
MFCD01633460
Specific activity:
5,000 units/mg protein
Recombinant:
expressed in E. coli
Concentration:
~0.1 mg/mL

$582.00

Check Cart for Availability
​
Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

recombinant

expressed in E. coli

Quality Segment

200

form

buffered aqueous solution

specific activity

5,000 units/mg protein

mol wt

20 kDa

concentration

~0.1 mg/mL

UniProt accession no.

P09237

relevant disease(s)

cancer

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... MMP7(4316)

General description

Matrix metalloproteinase-7 (MMP7) also referred to as matrilysin is encoded by the gene mapped to human chromosome 11q21-q22. MMP7 is a smallest member of MMP enzyme family and is highly expressed in cancer cells. MMP7 is exclusively released by epithelial cells.

Application

Matrix metalloproteinase-7 (MMP7) human has been used in in silico analysis of MMP-7 proteolysis of perlecan.

Biochem/physiol Actions

Matrix metalloproteinase-7 (MMP-7) catalyzes the cleavage of extracellular matrix (ECM) proteins such as proteoglycans, fibronectin, entactin, laminin, collagen III/ IV/ V/ IX/ X/ XI, type I/ II/ IV/ V gelatins, and elastin. Matrix metalloproteinase-7 facilitates initial stages of tumor progression. Activated MMP7 plays a vital role in human colorectal cancer (CRC) liver metastases. Overexpression of MMP7 is observed in various human cancers, such as breast, lung, prostate, esophagus, stomach, endometrium, and ovarian carcinomas, as well as esophageal squamous cell carcinomas. Increased expression of MMP7 is also associated with pathogenesis of demyelinating multiple sclerosis (MS) lesions. Both in silico and in vitro studies show that MMP7 degrades glycosylated and basement membrane bound perlecan and plays a vital role in prostate cancer cell invasion.

Physical form

Solution in 10 mM HEPES, 5 mM CaCl2, 150 mM NaCl

Analysis Note

One unit of enzyme activity is defined as the digestion of 1 μg of azocoll/min. at pH 7.5 and 37 °C.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
SAB1410789SAB4501894M8945
Matrix Metalloproteinase-7 human ~0.1 mg/mL, recombinant, expressed in E. coli, buffered aqueous solution

Sigma-Aldrich

M4565

Matrix Metalloproteinase-7 human

Anti-MMP7 antibody produced in rabbit purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

SAB1410789

Anti-MMP7 antibody produced in rabbit

Anti-MMP-7 antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB4501894

Anti-MMP-7 antibody produced in rabbit

Matrix Metalloproteinase-9 human recombinant, >90% (SDS-PAGE), buffered aqueous solution

Sigma-Aldrich

M8945

Matrix Metalloproteinase-9 human

description

~0.1 mg/mL, recombinant, expressed in E. coli, buffered aqueous solution

description

purified immunoglobulin, buffered aqueous solution

description

affinity isolated antibody

description

recombinant, >90% (SDS-PAGE), buffered aqueous solution

specific activity

5,000 units/mg protein

specific activity

-

specific activity

-

specific activity

-

Gene Information

human ... MMP7(4316)

Gene Information

human ... MMP7(4316)

Gene Information

human ... MMP7(4316)

Gene Information

human ... MMP9(4318)

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

concentration

~0.1 mg/mL

concentration

-

concentration

~1 mg/mL

concentration

-

recombinant

expressed in E. coli

recombinant

-

recombinant

-

recombinant

-

mol wt

20 kDa

mol wt

antigen 29.7 kDa

mol wt

antigen 29 kDa

mol wt

apparent mol wt ~93 kDa

flash_point_f

Not applicable

flash_point_c

Not applicable

wgk

WGK 1

Storage Class

12 - Non Combustible Liquids

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters