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Anti-Melan-A antibody, Mouse monoclonal

Name: Anti-Melan-A antibody, Mouse monoclonal
Brand: SIGMA
Price: 827 USD
Availability: InStock

clone A103, purified from hybridoma cell culture

Synonym(s):

Anti-MART1

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Size/SKU	Availability	Price
200 μL	Available to ship TODAYfromMILWAUKEE	$827.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.43

MDL number:

MFCD01633630

Conjugate:

unconjugated

Clone:

A103, monoclonal

Application:

ELISA (i), ICC, IHC, IP, WB

Citations:

$827.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

A103, monoclonal

form

buffered aqueous solution

mol wt

antigen ~22 kDa

species reactivity

human, canine

concentration

~2 mg/mL

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: 0.1-0.2 μg/mL using total cell extract of SKMEL19 cells

isotype

IgG1

UniProt accession no.

Q16655

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MLANA(2315)

Description

General description

Melan-A is also known as MART-1 (melanoma antigen recognized by T-cells 1). It is a transmembrane protein which is hydrophobic in nature. Melan-A is expressed in melanocytes and melanoma tumors.

Melan-A is a melanoma antigen recognized by T cells.

Monoclonal Anti-Melan-A (mouse IgG1 isotype) is derived from the hybridoma A103 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from mice immunized with a human recombinant Melan-A protein. Melan-A (also known as MART1) is a melanoma antigen recognized by T cells. The protein is expressed mainly in cells and tumors of melanocytic lineage and thus belongs to the melanocyte differentiation markers.

Immunogen

recombinant human Melan-A protein.

Application

Anti-Melan-A antibody, Mouse monoclonal has been used in:

enzyme-linked immunosorbent assay (ELISA)
immunoblotting
immunocytochemistry
immunoprecipitation
immunohistochemistry

Biochem/physiol Actions

Melan-A/MART1 may have a role in pigmentation since its expression pattern and sub cellular distribution is similar to other melanosomal proteins and correlates with melanin content. Melan-A is important for Pmel17 activity, forms a complex with it, and affects its expression, stability, trafficking, and processing that is required for melanosome structure and maturation. Thus, Melan-A is important for Pmel17 function and therefore it is important for mammalian pigmentation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4500949	MABF3201	HPA048662
Sigma-Aldrich M6570 Anti-Melan-A antibody, Mouse monoclonal	Sigma-Aldrich SAB4500949 Anti-MART-1 antibody produced in rabbit	Sigma-Aldrich MABF3201 Anti-MART-1/Melan-A Antibody, clone A103	Sigma-Aldrich HPA048662 Anti-MLANA antibody produced in rabbit
description clone A103, purified from hybridoma cell culture	description affinity isolated antibody	description -	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
species reactivity human, canine	species reactivity human	species reactivity human	species reactivity human
clone A103, monoclonal	clone polyclonal	clone A103, monoclonal	clone polyclonal
antibody form purified from hybridoma cell culture	antibody form affinity isolated antibody	antibody form purified antibody	antibody form affinity isolated antibody
Gene Information human ... MLANA(2315)	Gene Information human ... MLANA(2315)	Gene Information human ... MLANA(2315)	Gene Information human ... MLANA(2315)
biological source mouse	biological source rabbit	biological source mouse	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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