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MSST0010

SILu™Lite MAPK1 Mitogen Activated Protein Kinase 1 human

recombinant, expressed in HEK 293 cells, MS Protein Standard

Synonym(s):

Extracellular signal-regulated kinase 2 (Erk2), Mitogen-activated protein kinase 1 (MAPK1)

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50 μg
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$836.00

About This Item

NACRES:
NA.12
UNSPSC Code:
23201100
Assay:
≥95% (SDS-PAGE)
Recombinant:
expressed in HEK 293 cells

$836.00

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recombinant

expressed in HEK 293 cells

Quality Level

200

tag

His tagged

assay

≥95% (SDS-PAGE)

form

liquid

mol wt

43.8 kDa

suitability

suitable for mass spectrometry (internal calibrator)

UniProt accession no.

P28482

relevant disease(s)

cancer

storage temp.

−20°C

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SILu™Lite MAPK1 Mitogen Activated Protein Kinase 1 human recombinant, expressed in HEK 293 cells, MS Protein Standard

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MSST0020

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SILu™Prot MAPK3 Mitogen activated protein kinase 3 human recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C and 15N-labeled

Sigma-Aldrich

MSST0019

SILu™Prot MAPK3 Mitogen activated protein kinase 3 human

SILu™Lite AKT1, RAC-alpha serine/threonine-protein kinase human recombinant, expressed in HEK 293 cells, MS Protein Standard

Sigma-Aldrich

MSST0050

SILu™Lite AKT1, RAC-alpha serine/threonine-protein kinase human

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

suitability

suitable for mass spectrometry (internal calibrator)

suitability

suitable for mass spectrometry

suitability

suitable for mass spectrometry (standard)

suitability

suitable for mass spectrometry (internal calibrator)

form

liquid

form

liquid

form

liquid

form

liquid

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

mol wt

43.8 kDa

mol wt

45.5 kDa

mol wt

-

mol wt

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

SILu™Lite MAPK1 is a recombinant human MAPK1 expressed in human 293 cells. It is a monomer of 380 amino acids (including polyhistidine and flag tags), with an apparent molecular weight of 44 kDa. SILu™Lite MAPK1 is designed to be used as an internal standard for bioanalysis of MAPK1 in mass-spectrometry.

Biochem/physiol Actions

MAPK1 is a cytoplasmic protein that following activation is capable of translocating to the nucleus where it phosphorylates and regulates nuclear proteins (e.g., Elk-1, c-Myc, c-Jun, c-Fos, and C/EBP β). It is a protein serine/threonine kinase that is a member of the extracellular signal-regulated kinases (ERKs) which are activated in response to numerous growth factors and cytokines. Aberrations in the RAS-MAPK complex (of which MAPK1 is a downstream effector) are implicated in several human cancers, and this renders the pathway an attractive therapeutic target.

Physical form

Supplied as a 0.1 mg/mL solution of 20mM sodium phosphate, pH 8.0, 1M NaCl.

Other Notes

MDYKDDDDKGHHHHHHHHGGQAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS

Legal Information

This product is licensed under U.S. Patent No. 7,396,688 and foreign counterparts from E. I. du Pont de Nemours and Company. The purchase of this product conveys to the buyer the nontransferable right to use the purchased amount of the product for research and development only, including services for a third party for consideration. The buyer cannot sell or otherwise transfer this product, its components or materials made using this product or its components to a third party. Information about licenses for excluded uses is available from: E. I. du Pont de Nemours and Company; Attn: Associate Director, Commercial Development; DuPont Experimental Station E268; 200 Powdermill Rd.; Wilmington, DE 19803; 1-877-881-9787 (voice), 1-302-695-1437 (fax), [email protected].
SILu is a trademark of Sigma-Aldrich Co. LLC

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
115M4778V

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Global Trade Item Number

SKUGTIN
MSST0010-50UG04061833254929

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