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MSST0020

SILu™Lite MAPK3 Mitogen activated protein kinase 3 human

recombinant, expressed in HEK 293 cells, MS Protein Standard

Synonym(s):

Erk1, MAP kinase 3, p44

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50 μg
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$836.00

About This Item

NACRES:
NA.12
UNSPSC Code:
23201100
Assay:
≥95% (SDS-PAGE)
Recombinant:
expressed in HEK 293 cells

$836.00

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recombinant

expressed in HEK 293 cells

Quality Segment

200

assay

≥95% (SDS-PAGE)

form

liquid

mol wt

45.5 kDa

suitability

suitable for mass spectrometry

UniProt accession no.

P27361

storage temp.

−20°C

General description

SILu™ Lite MAPK3 is a recombinant human protein expressed in human 293 cells. It is a monomer of 399 amino acids (including N-terminal polyhistidine and flag tags), with a molecular weight of ~45.5 kDa. SILu™ Lite MAPK3 is an analytical standard designed to be used as starting material for preparation of calibrators and controls in LC-MS applications.

Biochem/physiol Actions

MAPK3, the first mammalian MAPK to be characterized and cloned, is commonly expressed in most tissues and is activated through the small guanosine triphosphatase Ras and sequential activation of the protein kinases Raf and MEK upon stimulation of cells with a broad range of extracellular signals. Erk was suggested to be a good marker for estradiol and tamoxifen effects. Alzheimer′s disease′s Erk1 and Erk2 index values were inversely correlated with disease duration, suggesting maximal efficacy for early diagnosis. In addition, differential Erk1 and Erk2 phosphorylation, could have important clinical utility for providing increased certainty in the positive diagnosis of AD, particularly in the early phase of disease progression.

Physical form

Supplied as a 0.1 mg/mL solution of 20mM sodium phosphate, pH 8.0, 1M NaCl.

Other Notes

MDYKDDDDKGHHHHHHHHGGQAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP

Legal Information

This product is licensed under U.S. Patent No. 7,396,688 and foreign counterparts from E. I. du Pont de Nemours and Company. The purchase of this product conveys to the buyer the nontransferable right to use the purchased amount of the product for research and development only, including services for a third party for consideration. The buyer cannot sell or otherwise transfer this product, its components or materials made using this product or its components to a third party. Information about licenses for excluded uses is available from: E. I. du Pont de Nemours and Company; Attn: Associate Director, Commercial Development; DuPont Experimental Station E268; 200 Powdermill Rd.; Wilmington, DE 19803; 1-877-881-9787 (voice), 1-302-695-1437 (fax), licensing@dupont.com.
SILu is a trademark of Sigma-Aldrich Co. LLC

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Sigma-Aldrich

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SILu™Lite AKT3, RAC-gamma serine/threonine-protein kinase human

description

recombinant, expressed in HEK 293 cells, MS Protein Standard

description

recombinant, expressed in HEK 293 cells, MS Protein Standard

description

recombinant, expressed in HEK 293 cells, SIL MS Protein Standard, 13C and 15N-labeled

description

recombinant, expressed in HEK 293 cells, MS Protein Standard

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

form

liquid

form

liquid

form

liquid

form

liquid

suitability

suitable for mass spectrometry

suitability

suitable for mass spectrometry (internal calibrator)

suitability

suitable for mass spectrometry (standard)

suitability

suitable for mass spectrometry (internal calibrator)

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

recombinant

expressed in HEK 293 cells

mol wt

45.5 kDa

mol wt

43.8 kDa

mol wt

-

mol wt

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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