Skip to Content
MilliporeSigma

Skip To

MTOX1016

OATP1B3 Knockout HepaRG™ Cells

human female liver (hepatocarcinoma and hepatitis C tumor)

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
1 vial
Usually ships in 3 weeks.
$1,040.00

About This Item

UNSPSC Code:
12352207
NACRES:
NA.81
Biological source:
human female liver (hepatocarcinoma and hepatitis C tumor)

$1,040.00


Usually ships in 3 weeks.

​
Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Product Name

OATP1B3 Knockout HepaRG™ Cells, 1 vial

biological source

human female liver (hepatocarcinoma and hepatitis C tumor)

Quality Segment

form

liquid

OMIM accession no.

storage temp.

−196°C

Gene Information

human ... OATP1B3(28234)

General description

HepaRG is a human hepatoma cell line. The cells possess a pseudodiploid karyotype and have been characterized as an oval ductular bipotent hepatic cell line as they have the ability to differentiate into both biliary and hepatocyte lineages in the presence of DMSO. HepaRG OATP1B3 knockout cells express the major xenobiotic sensors (PXR, CAR and AhR), drug transporters, phase I and II drug metabolizing enzymes as well as key hepatic transcription factors involved in stress response pathways.

Application

See technical bulletin for detailed protocols

Features and Benefits

Zinc finger nucleases (ZFN) mediated Knock-out of SLCO1B3 (MRP3) gene.

  • The frame-shift mutation of SLCO1B3 gene was confirmed by fragment length analysis and DNA sequencing.
  • Loss of functionality was confirmed by loss of transport of selective substrates in sandwich culture assay.

Analysis Note

Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification, cytochrome oxidase I (COI) analysis for cell line species confirmation.

Legal Information

These products are covered by the License Agreement as described in Exhibit 1, 2 and 3, in the technical bulletin.
HepaRG is a trademark of BioPredic International company

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
MTOX1019MTOX1012MTOX1097
description

1 vial

description

1 vial

description

1 vial

description

one vial

biological source

human female liver (hepatocarcinoma and hepatitis C tumor)

biological source

human female liver (Source Disease: Hepatocarcinoma and Hepatitis C)

biological source

human female liver (Source Disease: Hepatocarcinoma and Hepatitis C)

biological source

human male colorectal tissue (Source Disease: colon adenocarcinoma )

storage temp.

−196°C

storage temp.

−196°C

storage temp.

−196°C

storage temp.

−196°C

OMIM accession no.

605495

OMIM accession no.

-

OMIM accession no.

-

OMIM accession no.

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

Gene Information

human ... OATP1B3(28234)

Gene Information

human ... ABCB1(5243)

Gene Information

human ... ABCB1(1346307)

Gene Information

human ... ABCC10(89845)

form

liquid

form

liquid

form

liquid

form

liquid


Storage Class

12 - Non Combustible Liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library



Questions

Reviews

No rating value

Active Filters