N0164
Necrostatin-5
≥98% (HPLC), solid
Synonym(s):
2-[[3,4,5,6,7,8-hexahydro-3-(4-methoxyphenyl)-4-oxo[1]benzothieno[2,3-d]pyrimidin-2-yl]thio]-acetonitrile, 3-p-methoxyphenyl-5,6-tetramethylenothieno[2,3-d]pyrimidin-4-one-2-mercaptoethylcyanide
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Check Cart for Availability | $87.90 |
About This Item
Quality Segment
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
COc1ccc(cc1)N2C(=O)c3c4CCCCc4sc3N=C2SCC#N
InChI
1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3
InChI key
VGONMECBFMCKBS-UHFFFAOYSA-N
Biochem/physiol Actions
1 of 1
This Item | |||
|---|---|---|---|
| description ≥98% (HPLC), solid | description Necrostatin-1, CAS 4311-88-0, is a cell-permeable, potent, and selective blocker of necroptosis (EC50 = 494 nM in FADD-deficient Jurkat cells treated with TNF-α). | description ≥98% (HPLC) | description ≥97% (HPLC), powder |
| form solid | form crystalline solid | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥98% (HPLC) | assay ≥97% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
| solubility DMSO: >10 mg/mL | solubility methanol: 5 mg/mL, DMSO: 10 mg/mL | solubility DMSO: >10 mg/mL | solubility - |
| color white to off-white | color yellow | color - | color - |
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Aquatic Chronic 4 - Eye Irrit. 2
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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