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N0663

NS1643

≥98% (HPLC), solid

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Size/SKUAvailabilityPrice
5 mg
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$287.00

About This Item

Empirical Formula (Hill Notation):
C15H10F6N2O3
CAS Number:
Molecular Weight:
380.24
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

$287.00


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Quality Segment

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

Oc1ccc(cc1NC(=O)Nc2cc(ccc2O)C(F)(F)F)C(F)(F)F

InChI

1S/C15H10F6N2O3/c16-14(17,18)7-1-3-11(24)9(5-7)22-13(26)23-10-6-8(15(19,20)21)2-4-12(10)25/h1-6,24-25H,(H2,22,23,26)

InChI key

NJFVQMRYJZHGME-UHFFFAOYSA-N

Biochem/physiol Actions

NS1643 is ether-a-go-go (ERG) channel activator with EC50 = 10.5 μM in Xenopus oocytes and hERG channels expressed in HEK293 cells.
The new diphenylurea compound 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) was tested in hERG channel. In Xenopus laevis oocytes, NS1643 increased both steady-state and tail current at all voltages tested. The EC50 value for hERG channel activation was 10.5 μM. The effect could be reverted by application of the specific hERG channel inhibitor 4′-[[1-[2-(6-methyl-2-pyridyl)ethyl]-4-piperidinyl]carbonyl]-methanesulfonanilide (E-4031) at 100 nM. Application of NS1643 also resulted in a prolonged postrepolarization refractory time. hERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents a new antiarrhythmic approach.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
324470SML0672CYL4039
description

≥98% (HPLC), solid

description

A potent and selective inhibitor of the rapid type of inactivating inward-rectifying K+ current (IK, IR) (IC50 = 10 nM).

description

≥98% (HPLC)

description

Human ERG ion channel membrane preparation for Radioligand binding Assays.

form

solid

form

solid

form

powder

form

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 50 mg/mL, water: 50 mg/mL

solubility

DMSO: 20 mg/mL, clear

solubility

-

color

white to off-white

color

white to off-white

color

white to beige

color

-


Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Codes

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



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