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N1413

NSCI

≥97% (HPLC), solid

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Synonym(s):

1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$233.00

About This Item

Empirical Formula (Hill Notation):
C26H25N3O6S
CAS Number:
Molecular Weight:
507.56
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
solid

$233.00

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Quality Segment

assay

≥97% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H2O: insoluble

storage temp.

−20°C

SMILES string

COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N4CCC[C@H]4COc5cccnc5)cc1

InChI

1S/C26H25N3O6S/c1-34-20-8-6-18(7-9-20)16-28-24-11-10-22(14-23(24)25(30)26(28)31)36(32,33)29-13-3-4-19(29)17-35-21-5-2-12-27-15-21/h2,5-12,14-15,19H,3-4,13,16-17H2,1H3/t19-/m0/s1

InChI key

XDHJBIYJRNFDKS-IBGZPJMESA-N

Gene Information

Application

NSCI has been used as an apoptosis inhibitor to study its effects on caspase 9 activity in cultured tick cells. It has also been used as an apoptosis inhibitor in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to study anti-CD3-induced apoptosis in the cluster of differentiation 4 (CD4+) and cluster of differentiation 8 (CD8+) T cells from pleural effusions, mononuclear cells (PEMCs).

Biochem/physiol Actions

1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione (NSCI) is a nonpeptide caspase 3 selective inhibitor.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
HPA039769HPA007955
description

≥97% (HPLC), solid

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

assay

≥97% (HPLC)

assay

-

assay

-

form

solid

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

-

solubility

-

Gene Information

human ... CASP1(834), CASP3(836), CASP6(839), CASP7(840), SUMO1(7341)

Gene Information

human ... INSC(387755)

Gene Information

human ... MANSC1(54682)


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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