Key Documents

Nucleozin

Name: Nucleozin
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

Nucleozin, 1-(2-Chloro-4-nitrophenyl)-4-[(5-methyl-3-phenyl-4-isoxazolyl)carbonyl]-piperazine, [4-(2-Chloro-4-nitro-phenyl)-piperazin-1-yl]-(5-methyl-3-phenyl-isoxazol-4-yl)-methanone

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₁₉ClN₄O₄

CAS Number:

341001-38-5

Molecular Weight:

426.85

NACRES:

NA.77

PubChem Substance ID:

329818419

UNSPSC Code:

12352200

MDL number:

MFCD01426660

Assay:

≥98% (HPLC)

Form:

powder

Pricing and availability is not currently available.

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

yellow

solubility

DMSO: >15 mg/mL

storage temp.

2-8°C

SMILES string

Cc1onc(-c2ccccc2)c1C(=O)N3CCN(CC3)c4ccc(cc4Cl)[N+]([O-])=O

InChI

1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3

InChI key

OWXBJAPOSQSWAO-UHFFFAOYSA-N

Description

Application

Nucleozin may be used in anti-viral (anti-influenza) research to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an influenza A nucleoprotein (a multifunctional, RNA-binding protein necessary for virus replication) targeting drug candidate.

Biochem/physiol Actions

Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication.

Nucleozin targets influenza A nucleoprotein (NP), a multifunctional, RNA-binding protein necessary for virus replication. Nucleozin is effective in fighting H1N1, H3N2, and H5N1 flu virus strains by inducing the formation of NP aggregates and antagonizing its nuclear accumulation, leading to cessation of viral replication.

Nucleozin targets influenza A nucleoprotein, a multifunctional, RNA-binding protein necessary for virus replication. It induces the formation of nucleoptotein aggregates and inhibits its accumulation, interfering with viral replication. EC₅₀ is in the nM range. Nucleozin is effective in H1N1, H3N2, and H5N1 flu virus strains.

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This Item	492905	SML3289	A5251
Sigma-Aldrich N2790 Nucleozin	Sigma-Aldrich 492905 Nucleozin	Sigma-Aldrich SML3289 Synucleozid dihydrochloride	Sigma-Aldrich A5251 3-Acetylpyridine adenine dinucleotide
description ≥98% (HPLC), powder	description A cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells.	description ≥98% (HPLC)	description ≥85%
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥85%
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 200
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: >15 mg/mL	solubility DMSO: 20 mg/mL	solubility DMSO: 2 mg/mL, clear	solubility water: 50 mg/mL, clear, colorless to faintly yellow
color yellow	color yellow	color , White to very dark grey	color white to off-white

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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