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Monoclonal Anti-Neurofilament 160 antibody produced in mouse

Name: Monoclonal Anti-Neurofilament 160 antibody produced in mouse
Brand: SIGMA
Price: 572 USD
Availability: InStock

clone NN18, ascites fluid

Synonym(s):

Monoclonal Anti-Neurofilament medium chain

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Size/SKU	Availability	Price
100 μL	Check Cart for Availability	$572.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01322393

Conjugate:

unconjugated

Clone:

NN18, monoclonal

Application:

IHC (f), IHC (p), WB

Citations:

$572.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

NN18, monoclonal

mol wt

antigen 160 kDa

contains

15 mM sodium azide

species reactivity

human, pig

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:40 using human tissue sections, immunohistochemistry (frozen sections): suitable, western blot: suitable

isotype

IgG1

UniProt accession no.

P07197

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

chicken ... NEFM(396206)
human ... NEFM(4741)
mouse ... Nefm(18040)
rat ... Nefm(24588)

Description

General description

Monoclonal Anti-Neurofilament 160 (mouse IgG1 iso-type) is produced by the fusion mouse myeloma cells and splenocytes from an immunized mouse. Neurofilaments are composed of three sub-units- light NFL protein, medium NFM protein, heavy NFH protein. Along with there two other intermediate filaments are present α-internexin and peripherin. Neurofilaments are phosphoproteins.

Neurofilaments belong to the intermediate filament family and are expressed mainly in cells or tissues of neuronal origin. It is crucial for proper radial growth of axons.

Immunogen

neurofilaments from pig spinal cord.

Application

Monoclonal anti-neurofilament 160 antibody (diluted 1: 5000) can be used as internal loading controls in immunoblotting. It can also be used in whole-mount immunohistochemistry and western blot. Monoclonal anti-neurofilament 160 antibodies can be used for localization of neurofilaments of molecular weight 160,000 in cultured cells or tissues preparation.

Monoclonal anti-neurofilament 160 antibody has been used in

Immunoblotting.
Immunohistochemistry
Immunofluorescence

Biochem/physiol Actions

Mouse monoclonal anti-neurofilament 160 antibody reacts specifically with neurofilaments of molecular weight 160,000 but does not cross react with other intermediate filament proteins.

Neurofilaments play a role in axonal calibre as they help in movement of an impulse down the axon. Their activity depends on phosphorylation of neurofilaments.Mutations of neurofilaments causes Charcot-Marie-Tooth (CMT) disease. Accumulation of neurofilaments has been observed in many human neurological diseases like Alzheimer′s disease, progressive supranuclear palsy, diabetic neuropathy, and giant axonal neuropathy.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	N2787	N2912	N5389
Sigma-Aldrich N5264 Monoclonal Anti-Neurofilament 160 antibody produced in mouse	Sigma-Aldrich N2787 Monoclonal Anti-Neurofilament 160 antibody produced in mouse	Sigma-Aldrich N2912 Anti-Neurofilament 160/200 antibody, Mouse monoclonal	Sigma-Aldrich N5389 Monoclonal Anti-Neurofilament 200 antibody produced in mouse
description clone NN18, ascites fluid	description ~2 mg/mL, clone RMO44, purified immunoglobulin, buffered aqueous solution	description ~2 mg/mL, clone RMdO20, purified from hybridoma cell culture	description clone NE14, ascites fluid
clone NN18, monoclonal	clone RMO44, monoclonal	clone RMdO20, monoclonal	clone NE14, monoclonal
antibody form ascites fluid	antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture	antibody form ascites fluid
biological source mouse	biological source mouse	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity human, pig	species reactivity human, mouse, rat, zebrafish	species reactivity mouse, rat, human	species reactivity pig, mouse, chicken, bovine, guinea pig, rabbit, rat, human
Gene Information chicken ... NEFM(396206) human ... NEFM(4741) mouse ... Nefm(18040) rat ... Nefm(24588)	Gene Information human ... NEFM(4741) mouse ... Nefm(18040) rat ... Nefm(24588)	Gene Information human ... NEFH(4744), NEFM(4741) mouse ... Nefh(380684), Nefm(18040) rat ... Nefh(24587), Nefm(24588)	Gene Information human ... NEFH(4744)

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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