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N7537

NSC 663284

≥98% (HPLC), solid

Synonym(s):

6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione

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5 mg

Available to ship TODAYfromMILWAUKEE

$270.00
25 mg

Available to ship TODAYfromMILWAUKEE

$1,070.00

About This Item

Empirical Formula (Hill Notation):
C15H16ClN3O3
CAS Number:
Molecular Weight:
321.76
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
protect from light

$270.00


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Quality Segment

assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

red

solubility

DMSO: ≥10 mg/mL, H2O: insoluble

storage temp.

2-8°C

SMILES string

ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O

InChI

1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2

InChI key

BMKPVDQDJQWBPD-UHFFFAOYSA-N

Gene Information

Application

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Biochem/physiol Actions

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.
Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

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This Item
217692SML0270SCR060RF
description

≥98% (HPLC), solid

description

The CDC25 Phosphatase Inhibitor II, NSC 663284, also referenced under CAS 383907-43-5, controls the biological activity of CDC25 Phosphatase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

≥98% (HPLC)

description

-

form

solid

form

solid

form

powder

form

-

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

storage condition

protect from light

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

-

solubility

DMSO: ≥10 mg/mL, H2O: insoluble

solubility

DMSO: 5 mg/mL (Use only fresh, anhydrous DMSO.), ethanol: 5 mg/mL

solubility

DMSO: ≥2 mg/mL (warmed)

solubility

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

470.1 °F

Flash Point (°C)

243.4 °C

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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