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N8536

Anti-phospho-NFAT1 (pSer54) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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1 vial
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$920.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD06798499
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
-

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biological source

rabbit

Quality Segment

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse

technique(s)

western blot: 1:1000

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer54)

Gene Information

mouse ... Nfatc2(18019)

General description

Nuclear factor of activated T cells (NFAT) is a family of transcription factors implicated in multiple biological processes including cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. NFAT1 (also known as NFATc2 or NFATp) is a 154 kDa member of this family that is regulated by the calcium-dependent phosphatase calcineurin. When calcineurin is activated by calcium it dephosphorylates multiple residues in the regulatory domain of NFAT1, leading to its translocation to the nucleus and activation of its transcriptional activity. Once in the nucleus, NFAT proteins act synergistically with the AP-1 transcription factor complex to regulate the expression of multiple genes. Serine 54 in mouse NFAT1 has been shown to be important in the regulation of its transcriptional activity.
Rabbit polyclonal anti-phospho-NFAT1 (pSer54) antibody detects mouse NFAT1. Other species have not been tested.

Immunogen

synthetic phosphopeptide corresponding to a region of mouse NFAT1 that contains serine 54.

Application

Rabbit polyclonal anti-phospho-NFAT1 (pSer54) antibody is used to tag phospho-NFAT1 (pSer54) for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as immunoblotting, immunoprecipitation, and immunofluorescence. It is used as a probe to determine the presence and roles of phospho-NFAT1 (pSer54) in the regulation of transcription by NFAT1.

Physical form

Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anti-phospho-NFAT1 (pSer54) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

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Anti-NFATC2 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

HPA024369

Anti-NFATC2 antibody produced in rabbit

description

affinity isolated antibody, buffered aqueous solution

description

affinity isolated antibody

description

affinity isolated antibody

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

technique(s)

western blot: 1:1000

technique(s)

western blot: 1:500-1:1000, ELISA: 1:1000

technique(s)

immunofluorescence: 1:100-1:500, ELISA: 1:1000, western blot: 1:500-1:1000

technique(s)

immunohistochemistry: 1:50-1:200, ChIP: 1—10 μg (per reaction)

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

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Storage Class

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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