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O3139

Oxamflatin

≥98% (HPLC), solid

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Synonym(s):

(2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid

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Size/SKUAvailabilityPrice
1 mg

Estimated to ship onOctober 08, 2026fromMILWAUKEE

$212.00
5 mg

Available to ship TODAYfromMILWAUKEE

$723.00
$614.55

About This Item

Empirical Formula (Hill Notation):
C17H14N2O4S
CAS Number:
Molecular Weight:
342.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352203
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

$212.00

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Estimated to ship onOctober 08, 2026Details


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Quality Segment

assay

≥98% (HPLC)

form

solid

solubility

DMSO: soluble 13 mg/mL

storage temp.

2-8°C

SMILES string

ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1

InChI

1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+

InChI key

QRPSQQUYPMFERG-LFYBBSHMSA-N

Application

Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor:
  • to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells
  • to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation
  • to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system
  • to study its stand-alone effect on cytarabine-sensitive and resistant cells.

Biochem/physiol Actions

Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.
Histone deacetylase inhibitor; anti-cancer agent.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item
C6239C2992SML0527
description

≥98% (HPLC), solid

description

~98% (HPLC)

description

≥98% (HPLC), powder

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

~98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: soluble 13 mg/mL

solubility

H2O: insoluble, DMSO: >10 mg/mL

solubility

H2O: insoluble, DMSO: ≥10 mg/mL

solubility

DMSO: 5 mg/mL, clear (warmed)


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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