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Anti-PERK (C-terminal) antibody produced in rabbit

Name: Anti-PERK (C-terminal) antibody produced in rabbit
Brand: SIGMA
Price: 552 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-E2AK3, Anti-EIF2AK3, Anti-HsPEK, Anti-PEK, Anti-PRKR-like endoplasmic reticulum kinase, Anti-Pancreatic eIF2α kinase, Anti-WRS

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Size/SKU	Availability	Price
100 μL	Available to ship TODAYfromMILWAUKEE	$552.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

$552.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~150 kDa

species reactivity

human (predicted), mouse, rat

technique(s)

western blot: 1:500-1:1,000 using whole cell lysate of HEK-293T expressing PERK cells

UniProt accession no.

Q9NZJ5

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EIF2AK3(9451), Eif2ak3(13666)
mouse ... Eif2ak3(13666)
rat ... Eif2ak3(29702)

Description

General description

Protein kinase RNA-like endoplasmic reticulum kinase (PERK) belongs to a family of eukaryotic initiation factor 2 α (eIF2α) kinases. It is a transmembrane kinase that is highly expressed in the pancreas. PERK contains two main domains: a kinase domain and an N-terminal domain like inositol- requiring enzyme-1 (IRE1), a protein involved in the unfolded protein response (UPR).

Immunogen

synthetic peptide corresponding to amino acids 1078-1092 of mouse PERK, conjugated to KLH. This sequence is identical in rat and differs by one amino acid in human.

Application

Anti-PERK (C-terminal) antibody produced in rabbit has been used for western blotting and ERK (extracellular-signal-regulated kinase) phosphorylation assays.

Biochem/physiol Actions

Anti-PERK C-terminal specifically recognizes PERK.

Protein kinase RNA-like endoplasmic reticulum kinase (PERK) is an endoplasmic reticulum (ER) stress sensor which phosphorylates eukaryotic initiation factor 2 α (eIF2α), thereby reducing the translation of most messenger RNAs (mRNAs). In mice models of frontotemporal dementia, the suppression of translation in a PERK-eIF2α-dependent manner plays a key role in neuronal loss. PERK confers protection to heart against pressure overload-induced congestive heart failure. Mutations in this gene are linked with Wolcott-Rallison syndrome (WRS) which is characterized by permanent neonatal diabetes, exocrine-deficient pancreas, growth retardation and osteopenia.

Protein kinase RNA-like endoplasmic reticulum kinase (PERK) responds to distinct cellular stress signals.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4504517	SAB5700219	SAB4503650
$Anti-PERK (C-terminal) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich P0074 Anti-PERK (C-terminal) antibody produced in rabbit	Sigma-Aldrich SAB4504517 Anti-phospho-PKR (pThr⁴⁴⁶) antibody produced in rabbit	Sigma-Aldrich SAB5700219 Anti-Eif2ak2 antibody produced in rabbit	Sigma-Aldrich SAB4503650 Anti-E2AK3 antibody produced in rabbit
description IgG fraction of antiserum, buffered aqueous solution	description affinity isolated antibody	description -	description affinity isolated antibody
antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
shipped in dry ice	shipped in wet ice	shipped in wet ice	shipped in wet ice
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution

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