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P0111

Phenserine

≥98% (HPLC), solid

Synonym(s):

(−)-N-Phenylcarbamoyleseroline, 1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethyl-pyrrolo[2,3-b]indol-5-ol phenylcarbamate (ester)

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Size/SKUAvailabilityPrice
25 mg
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$165.00

About This Item

Empirical Formula (Hill Notation):
C20H23N3O2
CAS Number:
Molecular Weight:
337.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

$165.00


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Quality Segment

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

H2O: <2 mg/mL, DMSO: >5 mg/mL

storage temp.

2-8°C

SMILES string

[H][C@]12N(C)CC[C@@]1(C)c3cc(OC(=O)Nc4ccccc4)ccc3N2C

InChI

1S/C20H23N3O2/c1-20-11-12-22(2)18(20)23(3)17-10-9-15(13-16(17)20)25-19(24)21-14-7-5-4-6-8-14/h4-10,13,18H,11-12H2,1-3H3,(H,21,24)/t18-,20+/m1/s1

InChI key

PBHFNBQPZCRWQP-QUCCMNQESA-N

Biochem/physiol Actions

(-)-Phenserine, a phenylcarbamate derivative, is a selective, non-competitive inhibitor of acetylcholinesterase (AChE).
(-)-Phenserine, a phenylcarbamate derivative, is a selective, non-competitive inhibitor of acetylcholinesterase (AChE). (-)-Phenserine produces rapid, potent, and long-lasting AChE inhibition, in vivo. It is significantly less toxic than (-)-physostigmine. (-)-Phenserine improves cognitive performance in both young learning-impaired and elderly rats. Reduced secretion of β-amyloid (Abeta) has been observed in cell lines exposed to (-)-phenserine, occurring through translational regulation of β-amyloid precursor protein (beta-APP) mRNA via a non-cholinergic mechanism. These in vitro findings appear to translate in vivo into animal models and humans.

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
B7283B0477000BP685
description

≥98% (HPLC), solid

description

≥98% (HPLC), solid

description

European Pharmacopoeia (EP) Reference Standard

description

British Pharmacopoeia (BP) Reference Standard

form

solid

form

solid

form

-

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

room temp

storage temp.

-

storage temp.

2-8°C

solubility

DMSO: >5 mg/mL, H2O: <2 mg/mL

solubility

H2O: 10 mg/mL

solubility

-

solubility

-

color

off-white

color

-

color

-

color

-


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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