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Anti-p57^Kip2 antibody produced in rabbit

Name: Anti-p57<SUP>Kip2</SUP> antibody produced in rabbit
Brand: SIGMA
Price: 822 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-Kip2

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Size/SKU	Availability	Price
200 μg	Check Cart for Availability	$822.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01633561

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IP, WB

Citations:

$822.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 57 kDa

species reactivity

human, mouse (predicted), bovine

technique(s)

immunoprecipitation (IP): 5 μg using 0.5-1 mg of HeLa nuclear extract and a bovine brain nuclear extract, western blot: 2 μg/mL using HeLa nuclear extract and bovine brain nuclear extract

UniProt accession no.

P49918

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CDKN1C(1028)
mouse ... Cdkn1c(12577)

Description

General description

Cyclin-dependent kinase inhibitor p57 (CDKN1C) or p57KIP2 (kinase inhibitory protein) is a tumor suppressor gene. It is a 316 amino acid protein with conserved amino- and carboxy-terminal domains and sequences with proline-alanine repeats. During mouse embryogenesis, p57KIP2 transcript is highly expressed in skeletal muscles, brain, heart, lungs and eye. The gene encoding this protein is localized on human chromosome 11p15.4.

Immunogen

synthetic peptide corresponding to amino acids 303-316 of human Kip2, conjugated to KLH.

Application

Anti-p57Kip2 antibody produced in rabbit has been used in Western blotting.

Biochem/physiol Actions

Cyclin-dependent kinase inhibitor p57 (CDKN1C) or p57KIP2 (kinase inhibitory protein) plays a vital role as a tight-binding inhibitor of several G1 cyclin/cyclin-dependent kinase (CDK) complexes. It is a negative regulator of cell proliferation. Mutation in this gene has been associated with Beckwith-Wiedemann syndrome. p57Kip2 facilitates direct inhibition of DNA replication by binding to the proliferating cell nuclear antigen.

Physical form

Solution in 0.1 M Tris-glycine, pH 7.4, containing 0.15 M NaCl, and 0.05% sodium azide.

Preparation Note

Purified using protein A

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	ZRB2530	SAB5702602	HPA002924
$Anti-p57Kip2 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich P0357 Anti-p57^Kip2 antibody produced in rabbit	ZRB2530 Anti-p57Kip2 Antibody, clone 1H11 ZooMAb^® Rabbit Monoclonal	Sigma-Aldrich SAB5702602 Anti-CDKN1C/p57 Kip2 Antibody, clone 6T4E6, Rabbit Monoclonal	Sigma-Aldrich HPA002924 Anti-CDKN1C antibody produced in rabbit
description IgG fraction of antiserum, buffered aqueous solution	description recombinant, expressed in HEK 293 cells	description -	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
antibody form IgG fraction of antiserum	antibody form purified antibody	antibody form -	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
form buffered aqueous solution	form lyophilized	form liquid	form buffered aqueous glycerol solution
mol wt antigen 57 kDa	mol wt calculated mol wt 32.18 kDa, observed mol wt ~50 kDa	mol wt 50 kDa	mol wt -

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Storage Class

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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