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P0498

Anti-PRL-3 antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-PTP4A3, Anti-Phosphatase of Regenerating Liver

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Size/SKUAvailabilityPrice
200 μL
20 left in stock
$634.00
$657.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD07370459
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p), IP, WB CL
Citations:
9

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biological source

rabbit

Quality Segment

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~25 kDa

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:250-1:500 using protease digested tissue sections from human heart by biotin/ExtrAvidin®-peroxidase staining, immunoprecipitation (IP): 0.5-1 μL using preparation containing recombinant human PRL-3, western blot (chemiluminescent): 1:500-1:1,000 using whole extract of human HepG2 cells

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PTP4A3(11156)
mouse ... Ptp4a3(19245)

General description

Phosphatase of regenerating liver (PRL-3), also known as protein tyrosine phosphatase type IVA, member 3 (PTP4A3) is a dual-specificity phosphatase. It belongs to the phosphatases of regenerating liver family. The PTP4A3 gene is localized on human chromosome 8q24.3.

Immunogen

Synthetic peptide corresponding to amino acid residues of human PRL-3 with N-terminal added cysteine, conjugated to KLH. The corresponding sequence is identical in mouse.

Application

Anti-PRL-3 antibody produced in rabbit has been used in western blotting and immunohistochemistry.

Biochem/physiol Actions

Phosphatase of regenerating liver (PRL-3) promotes epithelial-mesenchymal transition. It also plays an essential role in cancer cell migration, invasion and metastasis. It dephosphorylates serine, threonine and tyrosine residues. The protein is overexpressed in various cancers. PTP4A3 associates with transcription factors and regulates gene transcription. In addition, it also regulates breast cancer cell proliferation and invasion. Thus, this protein acts as a potent therapeutic target for breast cancer.
Anti-PRL-3 recognizes human phosphatase of regenerating live (PRL)-3 and does not cross-react with human PRL-1 and PRL-2.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in frost-free freezers is also not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Legal Information

ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anti-PRL-3 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution

Sigma-Aldrich

P0498

Anti-PRL-3 antibody produced in rabbit

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Sigma-Aldrich

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Monoclonal Anti-PRL antibody produced in mouse

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Sigma-Aldrich

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PRL-1 (2-173) Active human

PRL-2 (2-167) Active human recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Sigma-Aldrich

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PRL-2 (2-167) Active human

description

IgG fraction of antiserum, buffered aqueous solution

description

Prestige Antibodies® Powered by Atlas Antibodies, clone CL6550, purified immunoglobulin, buffered aqueous glycerol solution

description

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

description

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

conjugate

-

antibody form

IgG fraction of antiserum

antibody form

purified immunoglobulin

antibody form

-

antibody form

-

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

-

biological source

rabbit

biological source

mouse

biological source

human

biological source

human

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

aqueous solution

form

aqueous solution

clone

polyclonal

clone

CL6550, monoclonal

clone

-

clone

-

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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