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P203

Phenamil methanesulfonate salt

PPARγ inducer, solid

Synonym(s):

3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt

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5 mg

Available to ship TODAYfromMILWAUKEE

$149.00
25 mg

Available to ship TODAYfromMILWAUKEE

$489.00

About This Item

Linear Formula:
C12H12ClN7O · CH3SO3H
CAS Number:
1161-94-0
Molecular Weight:
401.83
UNSPSC Code:
12352200
PubChem Substance ID:
24277869
NACRES:
NA.77
MDL number:
MFCD00274070
Form:
solid

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Product Name

Phenamil methanesulfonate salt, solid

form

solid

Quality Segment

color

yellow

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.5 mg/mL, DMSO: ≥5 mg/mL (with warming), 0.1 M HCl: insoluble, H2O: insoluble

storage temp.

2-8°C

SMILES string

CS(O)(=O)=O.Nc1nc(N)c(nc1Cl)C(=O)NC(=N)Nc2ccccc2

InChI

1S/C12H12ClN7O.CH4O3S/c13-8-10(15)19-9(14)7(18-8)11(21)20-12(16)17-6-4-2-1-3-5-6;1-5(2,3)4/h1-5H,(H4,14,15,19)(H3,16,17,20,21);1H3,(H,2,3,4)

InChI key

MHPIZTURFVSLTJ-UHFFFAOYSA-N

Gene Information

General description

Phenamil, a derivative of amiloride is an inhibitor of sodium channels including acid sensing ion channel (ASIC) and epithelial sodium channels (ENaC).

Application

Phenamil methanesulfonate salt has been used:
  • to stimulate adipocyte differentiation in 3T3 cells
  • to test its effect on lateral flagella expression in Vibrio shilonii
  • in nanoparticle preparation to test its effect on osteo/odontoblastic differentiation

Biochem/physiol Actions

Phenamil is an inducer of peroxisome proliferator-activated receptor γ (PPARγ) and inhibits diamine oxidase. By favoring tribbles homolog 3 (Trb3) expression, phenamil holds therapeutic potential to treat pulmonary artery hypertension (PAH) and idiopathic PAH. It is also a bone morphogenetic protein (BMP) activator, which favors osteogenesis and odontogenesis of stem cells.

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This Item
B2417A5585A9561
Phenamil methanesulfonate salt solid

Sigma-Aldrich

P203

Phenamil methanesulfonate salt

Benzamil hydrochloride hydrate ≥98% (HPLC)

Sigma-Aldrich

B2417

Benzamil hydrochloride hydrate

5-(N-Methyl-N-isobutyl)­amiloride ≥98% (TLC), powder

Sigma-Aldrich

A5585

5-(N-Methyl-N-isobutyl)­amiloride

5-(N,N-Hexamethylene)amiloride

Sigma-Aldrich

A9561

5-(N,N-Hexamethylene)amiloride

description

solid

description

≥98% (HPLC)

description

≥98% (TLC), powder

description

-

form

solid

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: insoluble, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.5 mg/mL, DMSO: ≥5 mg/mL (with warming), 0.1 M HCl: insoluble

solubility

methanol: 10 mg/mL, DMSO: >20 mg/mL

solubility

methanol: 9.80-10.20 mg/mL, clear, pale yellow to yellow

solubility

-

color

yellow

color

yellow

color

-

color

-

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

Gene Information

human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340), SLC9A1(6548), SLC9A5(6553)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768), Slc9a1(24782), Slc9a3(24784)

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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