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P3287

Protein kinase CβII isozyme human

>85% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

Synonym(s):

Ca2+-activated phospholipid-dependent serine-threonine kinase βII isozyme human, PKC βII human

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5 μg
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$610.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
EC Number:
2.7.1.37 (BRENDA, IUBMB)
MDL number:
MFCD03458219
Specific activity:
≥500 unit/mg solid
Assay:
>85% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected insect cells

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recombinant

expressed in baculovirus infected insect cells

assay

>85% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

≥500 unit/mg solid

mol wt

80 kDa by SDS-PAGE, calculated mol wt 76.9 kDa

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PRKCB(5579)

Biochem/physiol Actions

PKCβII is involved in glucose signaling pathways.
Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and γ. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and θ. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and ι.
Phosphorylation appears to be an important mechanism of regulation of all PKCs. PKC plays a role in the regulation of cell transformation, growth, differentiation, ruffling, vesicle trafficking, apoptosis and gene expression.

Physical form

Solution in 20 mM HEPES, pH 7.4; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 100 mM NaCl, 0.05% Triton X-100, and 50% glycerol.

Other Notes

One unit will transfer 1 nmol of phosphate to histone H3 in 1 min at pH 7.4 at 30 °C.

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Protein kinase CβII isozyme human >85% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

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Protein kinase Cα isozyme human ≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

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P1782

Protein kinase Cα isozyme human

description

>85% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

description

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

description

≥75% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution

description

≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

specific activity

≥500 unit/mg solid

specific activity

-

specific activity

-

specific activity

≥250 units/μg protein

Gene Information

human ... PRKCB(5579)

Gene Information

human ... PRKCD(5580)

Gene Information

human ... PRKCZ(5590)

Gene Information

human ... PRKCA(5578)

assay

>85% (SDS-PAGE)

assay

>95% (SDS-PAGE)

assay

≥75% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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