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P3449

Phloridzin dihydrate

From apple wood, ≥99% (HPLC), Na+-glucose cotransport inhibitor, powder

Synonym(s):

1-[2-(β-D-Glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone, Phloretin 2′-β-D-glucopyranoside, Phloretin 2′-β-D-glucoside, Phlorizin dihydrate

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100 mg

Available to ship TODAY

$66.40
500 mg

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$83.90
$71.31
1 g

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$156.00
5 g

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$427.00
10 g

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$731.00
$621.35

About This Item

Empirical Formula (Hill Notation):
C21H24O10 · 2H2O
CAS Number:
Molecular Weight:
472.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-487-1
MDL number:
Beilstein/REAXYS Number:
66621
Assay:
≥99% (HPLC)
Form:
powder

$66.40


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Product Name

Phloridzin dihydrate, from apple wood, ≥99% (HPLC)

biological source

apple wood

Quality Segment

assay

≥99% (HPLC)

form

powder

mp

113-114 °C (lit.)

SMILES string

O.O.OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc3ccc(O)cc3)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C21H24O10.2H2O/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10;;/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2;2*1H2/t16-,18-,19+,20-,21-;;/m1../s1

InChI key

XQWBNXSENPTIDY-YXMARJSJSA-N

Application

Phloridzin dihydrate has been used as:
  • a Na+-glucose cotransport inhibitor to test its effect in lowering blood glucose
  • a hexose carrier inhibitor to prevent glucose derivative 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) uptake in sycamore cells
  • a non-specific sodium-glucose co-transporter 2 (SGLT2) inhibitor in embryonic cardiomyocyte cell line H9C2 to investigate its protective effect on Dox-induced cytotoxicity

Biochem/physiol Actions

Phloridzin is a glycoside present in the leaves and bark of apple. It is also present in peel and pulp of the apple fruit. Phloridzin belongs to the dihydrochalcones class of compounds. Lactase catabolizes phloridzin to phloretin and glucose in small intestine epithelial cells. Phloridzin is an antidiabetic agent and is equally bioavailable as phloretin.

Features and Benefits

Used to induce experimental glycosuria.

Other Notes

Dihydrochalcone glycoside found in apple tree

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274313PHL80513PHL83918
description

from apple wood, ≥99% (HPLC)

description

99%

description

phyproof® Reference Substance

description

phyproof® Reference Substance

assay

≥99% (HPLC)

assay

99%

assay

≥98.0% (HPLC)

assay

≥95.0% (HPLC)

form

powder

form

powder

form

-

form

-

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

mp

113-114 °C (lit.)

mp

113-114 °C (lit.)

mp

-

mp

-

biological source

apple wood

biological source

-

biological source

-

biological source

-


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Pictograms

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Signal Word

Warning

Hazard Codes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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