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P8390

Picrotoxinin

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Size/SKUAvailabilityPrice
250 mg

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$275.00

About This Item

Empirical Formula (Hill Notation):
C15H16O6
CAS Number:
17617-45-7
Molecular Weight:
292.28
NACRES:
NA.77
PubChem Substance ID:
24898746
UNSPSC Code:
41116107
MDL number:
MFCD00078765
Form:
powder

$275.00

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form

powder

Quality Segment

SMILES string

[H][C@@]12OC(=O)[C@]([H])([C@@H]1C(C)=C)[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@@]2([H])[C@]35C

InChI

1S/C15H16O6/c1-5(2)7-8-11(16)19-9(7)10-13(3)14(8,18)4-6-15(13,21-6)12(17)20-10/h6-10,18H,1,4H2,2-3H3/t6-,7+,8+,9-,10-,13-,14-,15+/m1/s1

InChI key

PIMZUZSSNYHVCU-KBLUICEQSA-N

General description

Picrotoxinin is a component of picrotoxin and can be derived from plants. It is a non-nitrogenous compound.

Application

Picrotoxinin has been used as an agonist of taste 2 receptor member 14 (TAS2R14) to perform an array-based bitter receptor screening assay and to study the effect of calcium buffering and calcium sensor type on its sensitivity.

Biochem/physiol Actions

Picrotoxinin acts as a potent convulsant.
GABAA receptor antagonist; binds to the GABA receptor-linked Cl− channel.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glycine Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Other Notes

Active component of picrotoxin

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This Item
PHL80339Y0001528P1675
Picrotoxinin

Sigma-Aldrich

P8390

Picrotoxinin

Picrotoxinin phyproof® Reference Substance

PHL80339

Picrotoxinin

Picrotoxinin European Pharmacopoeia (EP) Reference Standard

Y0001528

Picrotoxinin

Picrotoxin powder

Sigma-Aldrich

P1675

Picrotoxin

description

-

description

phyproof® Reference Substance

description

European Pharmacopoeia (EP) Reference Standard

description

powder

form

powder

form

-

form

-

form

powder

Quality Level

200

Quality Level

-

Quality Level

-

Quality Level

200

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Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Codes

H300

Precautionary Statements

P301 + P310 + P330

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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