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P8538

Protein Kinase Cδ isozyme human

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

Synonym(s):

Ca2+-activated phospholipid-dependent serine-threonine kinase δ isozyme human, PKCδ human

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5 μg
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$896.00

About This Item

UNSPSC Code:
51111800
NACRES:
NA.32
EC Number:
2.7.1.37 (BRENDA, IUBMB)
MDL number:
MFCD03458221
Assay:
>95% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected insect cells

$896.00

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recombinant

expressed in baculovirus infected insect cells

Quality Segment

assay

>95% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

74-79 kDa by SDS-PAGE

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PRKCD(5580)

Biochem/physiol Actions

PKCδ is involved in the induction of apoptosis in many cell types.
Protein Kinase C (PKC) is a serine/threonine kinase that is activated intracellularly by signal transduction pathways that produce DAG from phosphatidylinositol diphosphate (PIP2) and phosphatidylcholine (PC) through the action of various activated phospholipases. Phorbol esters also stimulate PKC. At least 11 PKC isozymes have been identified that differ in primary structure, tissue distribution, subcellular localization, response to extracellular signals, and substrate specificity. The isozymes can be grouped into three subfamilies. Members of the first family require Ca2+ and phospholipid and include PKCα, βI, βII, and γ. Members of the second family are phospholipid-dependent but Ca2+-independent, and include PKCδ, ε, η, and θ. Members of the third family are not activated by either DAG or phorbol esters and include PKCξ, μ, and ι.
Phosphorylation appears to be an important mechanism of regulation of all PKCs. PKC plays a role in the regulation of cell transformation, growth, differentiation, ruffling, vesicle trafficking, apoptosis and gene expression.

Physical form

Solution in 20 mM HEPES, pH 7.4; 2 mM EDTA, 2 mM EGTA, 5 mM DTT, 100 mM NaCl, 0.05% Triton X-100, and 50% glycerol.

Other Notes

One unit will transfer 1 nmol of phosphate to PKC epsilon substrate peptide in 1 min at pH 7.4 at 30 °C.

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Protein Kinase Cδ isozyme human >95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

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Protein kinase Cα isozyme human

description

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

description

>85% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

description

≥75% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution

description

≥70% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

assay

>95% (SDS-PAGE)

assay

>85% (SDS-PAGE)

assay

≥75% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

Gene Information

human ... PRKCD(5580)

Gene Information

human ... PRKCB(5579)

Gene Information

human ... PRKCZ(5590)

Gene Information

human ... PRKCA(5578)

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−70°C

UniProt accession no.

Q05655

UniProt accession no.

P05771

UniProt accession no.

Q05513

UniProt accession no.

P17252

Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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