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P8615

Phosphoinositide 3-kinase p110γ human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

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Synonym(s):

PI3K p110γ human, Phosphatidylinositol 3-kinase p110γ human

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10 μg
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$899.00

About This Item

UNSPSC Code:
12352207
NACRES:
NA.32
MDL number:
MFCD03457993
Specific activity:
~4.5 units/mg protein
Assay:
≥95% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected insect cells

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recombinant

expressed in baculovirus infected insect cells

Quality Segment

assay

≥95% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

~4.5 units/mg protein

UniProt accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PIK3CG(5294)

General description

Phosphatidylinositol 3-kinase p110γ /phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ (PIK3CG) gene, with 12 exons spanning 43 kb on genomic DNA, is mapped to human chromosome 7q22.3. PIK3CG belongs to the family of genes coding for enzymes that phosphorylate the 3′-hydroxyl of phosphatidylinositol.

Biochem/physiol Actions

PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
Phosphatidylinositol 3-kinase p110γ is implicated in the development of eosinophilic inflammation. Thus, inhibition of PI3Kγ expression can be considered as a potential therapeutic method for treating eosinophil-related diseases, including asthma. Knockdown of PIK3CG gene inhibits the PI3K-Akt/PKB signaling pathway, which is essential for tumorigenesis and the progression of colorectal cancers. Mutation in the gene is associated with the development of autistic disorder.

Physical form

Solution in 10 mM HEPES, pH 7.5, 100 mM NaCl, 0.5 mM MgCl2, 50% glycerol.

Other Notes

1 unit will transfer 1 nmol of phosphate/min, using phosphatidylinositol as substrate.

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Phosphoinositide 3-kinase p110γ human ≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

Sigma-Aldrich

P8615

Phosphoinositide 3-kinase p110γ human

PI3 kinase (p120g) Active human recombinant, expressed in baculovirus infected insect cells, ≥90% (SDS-PAGE)

Sigma-Aldrich

SRP0237

PI3 kinase (p120g) Active human

PI3 kinase [p110a(E545K)/p85a] Active human recombinant, expressed in baculovirus infected insect cells, ≥55% (SDS-PAGE)

Sigma-Aldrich

SRP0234

PI3 kinase [p110a(E545K)/p85a] Active human

PI3 kinase [p110a(H1047R)/p85a] Active human recombinant, expressed in baculovirus infected insect cells, ≥60% (SDS-PAGE)

Sigma-Aldrich

SRP0235

PI3 kinase [p110a(H1047R)/p85a] Active human

description

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

description

recombinant, expressed in baculovirus infected insect cells, ≥90% (SDS-PAGE)

description

recombinant, expressed in baculovirus infected insect cells, ≥55% (SDS-PAGE)

description

recombinant, expressed in baculovirus infected insect cells, ≥60% (SDS-PAGE)

assay

≥95% (SDS-PAGE)

assay

≥90% (SDS-PAGE)

assay

≥55% (SDS-PAGE)

assay

≥60% (SDS-PAGE)

specific activity

~4.5 units/mg protein

specific activity

≥1.4 pmol/min-μg

specific activity

≥800 pmol/min-μg

specific activity

≥1770 pmol/min-μg

Gene Information

human ... PIK3CG(5294)

Gene Information

human ... PIK3CG(5294)

Gene Information

human ... PIK3CA(5290)

Gene Information

human ... PIK3CA(5290)

form

buffered aqueous glycerol solution

form

aqueous solution

form

aqueous solution

form

aqueous solution

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

recombinant

expressed in baculovirus infected insect cells

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
095K0633
081K0007
052K1620
013K0308
040M1508

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