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PD 169316

Name: PD 169316
Brand: SIGMA
Price: 227 USD
Availability: InStock

≥98% (HPLC), solid

Synonym(s):

4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole

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Size/SKU	Availability	Price
5 mg	Available to ship TODAYfromMILWAUKEE	$227.00

About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₃FN₄O₂

CAS Number:

152121-53-4

Molecular Weight:

360.34

NACRES:

NA.77

PubChem Substance ID:

24278156

UNSPSC Code:

12352200

MDL number:

MFCD12405019

Assay:

≥98% (HPLC)

Form:

solid

$227.00

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

faint yellow to dark orange

solubility

DMSO: >10 mg/mL, H₂O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4

InChI

1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)

InChI key

BGIYKDUASORTBB-UHFFFAOYSA-N

Gene Information

human ... MAPK14(1432)

Description

General description

PD 169316 is a pyridinyl imidazole compound. It is a potential inhibitor of p38 mitogen-activated protein kinases. It also inhibits signalling transforming growth factor β (TGFβ), particularly in human ovarian cancer cells.

Application

PD 169316 has been used for the inhibition of p38 enzyme in human hepatocytes. It has been used in culture media to promote embryoid bodies differentiation.

Biochem/physiol Actions

Potent, cell-permeable and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item	S7067	513030	513033
Sigma-Aldrich P9248 PD 169316	Sigma-Aldrich S7067 SB 202190	Sigma-Aldrich 513030 PD 169316	Sigma-Aldrich 513033 PD 168393
description ≥98% (HPLC), solid	description ≥98% (HPLC)	description A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).	description A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC₅₀ = 700 pM).
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form powder	form solid	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C
solubility H₂O: insoluble, DMSO: >10 mg/mL	solubility DMSO: 10 mg/mL, clear	solubility DMSO: 10 mg/mL	solubility DMSO: 200 mg/mL
color faint yellow to dark orange	color faintly yellow, to beige	color orange-yellow	color yellow

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Pictograms

GHS06,GHS05

Signal Word

Danger

Hazard Codes

H301,H315,H318,H335

Precautionary Statements

P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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